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dc.contributor.authorCastellanos, Maria Isabel
dc.contributor.authorMas-Moruno, Carlos
dc.contributor.authorGrau, Anna
dc.contributor.authorSerra-Picamal, Xavier
dc.contributor.authorTrepat, Xavier
dc.contributor.authorAlbericio Palomera, Fernando
dc.contributor.authorJoner, Michael
dc.contributor.authorGil Mur, Francisco Javier
dc.contributor.authorGinebra, Maria-Pau
dc.contributor.authorManero, José María
dc.contributor.authorPEGUEROLES, MARTA
dc.date.accessioned2021-11-11T18:32:03Z
dc.date.available2021-11-11T18:32:03Z
dc.date.issued2017
dc.identifier.citationCastellanos, Maria Isabel; Mas Moruno, Carlos; Grau, Anna [et al.]. Functionalization of CoCr surfaces with cell adhesive peptides to promote HUVECs adhesion and proliferation. Applied Surface Science, 2017, 393, p. 82-92. Disponible en: <https://www.sciencedirect.com/science/article/abs/pii/S0169433216319857?via%3Dihub>. Fecha de acceso: 11 nov. 2021. DOI: 10.1016/j.apsusc.2016.09.107ca
dc.identifier.issn0169-4332ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/2934
dc.description.abstractBiomimetic surface modification with peptides that have specific cell-binding moieties is a promising approach to improve endothelialization of metal-based stents. In this study, we functionalized CoCr surfaces with RGDS, REDV, YIGSR peptides and their combinations to promote endothelial cells (ECs) adhesion and proliferation. An extensive characterization of the functionalized surfaces was performed by XPS analysis, surface charge and quartz crystal microbalance with dissipation monitoring (QCM-D), which demonstrated the successful immobilization of the peptides to the surface. Cell studies demonstrated that the covalent functionalization of CoCr surfaces with an equimolar combination of RGDS and YIGSR represents the most powerful strategy to enhance the early stages of ECs adhesion and proliferation, indicating a positive synergistic effect between the two peptide motifs. Although these peptide sequences slightly increased smooth muscle cells (SMCs) adhesion, these values were ten times lower than those observed for ECs. The combination of RGDS with the REDV sequence did not show synergistic effects in promoting the adhesion or proliferation of ECs. The strategy presented in this study holds great potential to overcome clinical limitations of current metal stents by enhancing their capacity to support surface endothelialization.en
dc.format.extent37ca
dc.language.isoengca
dc.publisherElsevierca
dc.relation.ispartofApplied Surface Scienceca
dc.relation.ispartofseries393;
dc.rights© 2016 Elsevier B.V. All rights reserved.ca
dc.subject.otherAliatge CoCrca
dc.subject.otherFuncionalització superficialca
dc.subject.otherPèptids adhesius cel·lularsca
dc.subject.otherProliferació HUVECca
dc.subject.otherEndotelialitzacióca
dc.subject.otherAdhesió SMCca
dc.subject.otherAleación de CoCres
dc.subject.otherFuncionalización de superficiees
dc.subject.otherPéptidos adhesivos celulareses
dc.subject.otherProliferación de HUVECes
dc.subject.otherEndotelizaciónes
dc.subject.otherAdherencia de SMCes
dc.subject.otherCoCr alloyen
dc.subject.otherSurface functionalizationen
dc.subject.otherCell adhesive peptidesen
dc.subject.otherHUVEC proliferationen
dc.subject.otherEndothelializationen
dc.subject.otherSMCs adhesionen
dc.titleFunctionalization of CoCr surfaces with cell adhesive peptides to promote HUVECs adhesion and proliferationen
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/MAT2012-30706
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/321985
dc.subject.udc616.3ca
dc.identifier.doihttp://dx.doi.org/10.1016/j.apsusc.2016.09.107ca


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