Ciències Bàsiques: Recent submissions

Now showing items 21-40 of 65

    • Differential effects of muscarinic receptor blockade in prelimbic cortex on acquisition and memory formation of an odor-reward task 

      Carballo-Márquez, Anna; Vale-Martínez, Anna; Guillazo-Blanch, Gemma; Torras-Garcia, Meritxell; Boix-Trelis, Núria; Martí-Nicolovius, Margarita (Learning Memory, 2007)
      The present experiments determined the consequences of blocking muscarinic cholinergic receptors of the prelimbic (PL) cortex in the acquisition and retention of an odor-reward associative task. Rats ...

    • Efficiency and precision of microRNA biogenesis modes in plants 

      Moro, Belén; Chorostecki, Uciel; Arikit, Siwaret; Suarez, Irina P.; Höbartner, Claudia; Rasia, Rodolfo M.; Meyers, Blake C.; Palatnik, Javier F. (Nucleic Acids Research, 2018)
      Many evolutionarily conserved microRNAs (miRNAs) in plants regulate transcription factors with key functions in development. Hence, mutations in the core components of the miRNA biogenesis machinery ...

    • PhylomeDB V5: an expanding repository for genome-wide catalogues of annotated gene phylogenies 

      Fuentes, Diego; Molina, Manuel; Chorostecki, Uciel; Capella-Gutiérrez, Salvador; Marcet-Houben, Marina; Gabaldón, Toni (Nucleic Acids Research, 2022)
      PhylomeDB is a unique knowledge base providing public access to minable and browsable catalogues of pre-computed genome-wide collections of annotated sequences, alignments and phylogenies (i.e. phylomes) ...

    • Spatial control of gene expression by miR319-regulated TCP transcription factors in leaf development 

      Bresso, Edgardo G.; Chorostecki, Uciel; Rodriguez, Ramiro E.; Palatnik, Javier F.; Schommer, Carla (Plant Physiology, 2018)
      The characteristic leaf shapes we see in all plants are in good part the outcome of the combined action of several transcription factor networks that translate into cell division activity during the ...

    • Identification of key sequence features required for microRNA biogenesis in plants 

      Rojas, Arantxa M. L.; Drusin, Salvador I.; Chorostecki, Uciel; Mateos, Julieta L.; Moro, Belén; Bologna, Nicolas G.; Bresso, Edgardo G.; Schapire, Arnaldo; Rasia, Rodolfo M.; Moreno, Diego M.; Palatnik, Javier F. (Nature Communications, 2020)
      MicroRNAs (miRNAs) are endogenous small RNAs of ∼21 nt that regulate multiple biological pathways in multicellular organisms. They derive from longer transcripts that harbor an imperfect stem-loop ...

    • MetaPhOrs 2.0: integrative, phylogeny-based inference of orthology and paralogy across the tree of life 

      Chorostecki, Uciel; Molina, Manuel; Pryszcz, Leszek P.; Gabaldón, Toni (Nucleic Acids Research, 2020)
      Inferring homology relationships across genes in different species is a central task in comparative genomics. Therefore, a large number of resources and methods have been developed over the years. Some ...

    • Structural characterization of NORAD reveals a stabilizing role of spacers and two new repeat units 

      Chorostecki, Uciel; Saus, Ester; Gabaldón, Toni (Computational and Structural Biotechnology Journal, 2021)
      Long non-coding RNAs (lncRNAs) can perform a variety of key cellular functions by interacting with proteins and other RNAs. Recent studies have shown that the functions of lncRNAS are largely mediated ...

    • The plant noncoding transcriptome: a versatile environmental sensor 

      Chorostecki, Uciel; Bologna, Nicolas G.; Ariel, Federico (The EMBO Journal, 2023)
      Plant noncoding RNA transcripts have gained increasing attention in recent years due to growing evidence that they can regulate developmental plasticity. In this review article, we comprehensively analyze ...

    • Identification of new microRNA-regulated genes by conserved targeting in plant species 

      Chorostecki, Uciel; Crosa, Valeria A.; Lodeyro, Anabella F.; Bologna, Nicolás G.; Martin, Ana P.; Carrillo, Néstor; Schommer, Carla; Palatnik, Javier F. (Nucleic Acids Research, 2012)
      MicroRNAs (miRNAs) are major regulators of gene expression in multicellular organisms. They recognize their targets by sequence complementarity and guide them to cleavage or translational arrest. It is ...

    • Multiple RNA recognition patterns during microRNA biogenesis in plants 

      Bologna, Nicolás G.; Schapire, Arnaldo L.; Zhai, Jixian; Chorostecki, Uciel; Boisbouvier, Jerome; Meyers, Blake C.; Palatnik, Javier F. (Genome Research, 2013)
      MicroRNAs (miRNAs) derive from longer precursors with fold-back structures. While animal miRNA precursors have homogenous structures, plant precursors comprise a collection of fold-backs with variable ...

    • comTAR: a web tool for the prediction and characterization of conserved microRNA targets in plants 

      Chorostecki, Uciel; Palatnik, Javier F. (Bioinformatics, 2014)
      Motivation: MicroRNAs (miRNAs) are major regulators of gene expression in plants and animals. They recognize their target messenger RNAs (mRNAs) by sequence complementarity and guide them to cleavage ...

    • Evolutionary footprints reveal insights into plant MicroRNA biogenesis 

      Chorostecki, Uciel; Moro, Belen; Rojas, Arantxa M.L.; Debernardi, Juan M.; Schapire, Arnaldo L.; Notredame, Cedric; Palatnik, Javier F. (The Plant Cell, 2017)
      MicroRNAs (miRNAs) are endogenous small RNAs that recognize target sequences by base complementarity and play a role in the regulation of target gene expression. They are processed from longer precursor ...

    • Skull fractures by glass bottles tested on cadaveric heads 

      Lorente, Ana I.; Maza-Peón, Samuel; Hidalgo-García, César; López-de-Celis, Carlos; Rodríguez-Sanz, Jacobo; Pérez-Bellmunt, Albert; Maza-Frechín, Mario (International Journal of Legal Medicine, 2023)
      Head trauma is frequently related to the misuse of drinking vessels as weapons. Forensic reports usually evaluate these blunt injuries as having occurred in scenarios where the alcohol intake is high. ...

    • Engineering a genome reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo 

      Garrido, Victoria; Piñero Lambea, Carlos; Rodriguez Arce, Irene; Paetzold, Bernhard; Ferrar, Tony; Weber, Marc; Garcia Ramallo, Eva; Gallo López, Carolina; Collantes, María; Penuelas, Ivan; Serrano, Luis; Grillo, Maria-Jesus; Lluch, Maria (Molecular Systems Biology, 2021)
      Bacteria present a promising delivery system for treating human diseases. Here, we engineered the genome-reduced human lung pathogen Mycoplasma pneumoniae as a live biotherapeutic to treat biofilm-associated ...

    • Modeling cell adhesion and proliferation: a cellular-automata based approach 

      Vivas, J.; Garzón Alvarado, D.; Cerrolaza, Miguel (Advanced Modeling and Simulation in Engineering Sciences, 2015)
      Background: Cell adhesion is a process that involves the interaction between the cell membrane and another surface, either a cell or a substrate. Unlike experimental tests, computer models can simulate ...

    • Influence of bone-level dental implants placement and of cortical thickness on osseointegration: in silico and in vivo analyses 

      Gil, FJ; Sandino, Clara; Cerrolaza, Miguel; Perez, Roman; Herrero-Climent, Mariano; RÍOS-CARRASCO, BLANCA; Ríos-Santos, JV; Brizuela Velasco, Aritza (Journal of Clinical Medicine, 2022)
      The purpose of this research is to study the biomechanical response of dental implants in bone-level type locations, 0.5 mm above and below the bone level. In addition, the influence of the thickness ...

    • A simplified scheme for piezoelectric anisotropic analysis in human vertebrae using integral methods 

      De J. Duarte, Vannessa; Thoeni, Klaus; Garzón-Alvarado, Diego; Cerrolaza, Miguel (Mathematical Problems in Engineering, 2018)
      This paper outlines a computational model for the analysis of the piezoelectric behaviour of the vertebral body remodelling process. Particular attention is paid to the algorithms for the simulation of ...

    • Simplified qualitative discrete numerical model to determine cracking pattern in brittle materials by means of finite element method 

      Ochoa Avendaño, Jhon Freddy; Garzon-Alvarado, D. A.; Linero, Dorian L.; Cerrolaza, M. (Mathematical Problems in Engineering, 2017)
      This paper presents the formulation, implementation, and validation of a simplified qualitative model to determine the crack path of solids considering static loads, infinitesimal strain, and plane ...

    • Improved dynamical particle swarm optimization method for structural dynamics 

      Annicchiarico, William; Cerrolaza, Miguel (Mathematical Problems in Engineering, 2019)
      A methodology to the multiobjective structural design of buildings based on an improved particle swarm optimization algorithm is presented, which has proved to be very efficient and robust in nonlinear ...

    • Application of percutaneous needle electrolysis does not elicit temperature changes: an in vitro cadaveric study 

      Borrella-Andrés, Sergio; Malo-Urriés, Miguel; Albert, Pérez-Bellmunt; Arias-Buría, José L.; Rodríguez-Sanz, Jacobo; Albarova-Corral, María Isabel; González Rueda, Vanessa; Gallego-Sendarrubias, Gracia M.; Fernández de Las Peñas, César; López de Celis, Carlos (International Journal of Environmental Reseacrh and Public Health, 2022)
      Percutaneous needle electrolysis (PNE) consists of the ultrasound-guided application of a galvanic electrical current through a solid filament needle. One proposed therapeutic mechanism for this ...