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Modeling cell adhesion and proliferation: a cellular-automata based approach
(Springer Nature, 2015)
Background: Cell adhesion is a process that involves the interaction between the cell membrane and another surface, either a cell or a substrate. Unlike experimental tests, computer models can simulate ...
Hormone-induced repression of genes requires BRG1-mediated H1.2 deposition at target promoters
(EMBO Press, 2016)
Eukaryotic gene regulation is associated with changes in chromatin compaction that modulate access to DNA regulatory sequences relevant for transcriptional activation or repression. Although much is ...
Simplified qualitative discrete numerical model to determine cracking pattern in brittle materials by means of finite element method
(Hindawi, 2017)
This paper presents the formulation, implementation, and validation of a simplified qualitative model to determine the crack path of solids considering static loads, infinitesimal strain, and plane ...
Regulation of actin dynamics during structural plasticity of dendritic spines: signaling messengers and actin-binding proteins
(Elsevier, 2018-09)
Activity-dependent plasticity of synaptic structure and function plays an essential role in neuronal development and in cognitive functions including learning and memory. The formation, maintenance and ...
Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation
(Springer Nature, 2019)
Manipulation of neuronal activity using two-photon excitation of azobenzene photoswitches with near-infrared light has been recently demonstrated, but their practical use in neuronal tissue to photostimulate ...
Unliganded progesterone receptor governs estrogen receptor gene expression by regulating DNA methylation in breast cancer cells
(MDPI, 2018)
Breast cancer prognosis and response to endocrine therapy strongly depends on the expression of the estrogen and progesterone receptors (ER and PR, respectively). Although much is known about ERα gene ...
Improved dynamical particle swarm optimization method for structural dynamics
(Hindawi, 2019)
A methodology to the multiobjective structural design of buildings based on an improved particle swarm optimization algorithm is presented, which has proved to be very efficient and robust in nonlinear ...
ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling
(American Association for the Advancement of Science, 2016)
Key nuclear processes in eukaryotes, including DNA replication, repair, and gene regulation, require extensive chromatin remodeling catalyzed by energy-consuming enzymes. It remains unclear how the ATP ...
Functional characterization of a novel non-coding mutation “Ghent +49A > G” in the iron-responsive element of L-ferritin causing hereditary hyperferritinaemia-cataract syndrome
(Springer Nature, 2017)
Hereditary hyperferritinaemia-cataract syndrome (HHCS) is a rare disorder usually caused by heterozygous mutations in the iron-responsive element (IRE) in the 5′ untranslated region (5′UTR) of the ...
ATP, Mg2+, nuclear phase separation, and genome accessibility
(Elsevier, 2019)
Misregulation of the processes controlling eukaryotic gene expression can result in disease. Gene expression is influenced by the surrounding chromatin; hence the nuclear environment is also of vital ...