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Counter-propagating dual-trap optical tweezers based on linear momentum conservation
(AIP Publishing, 2013)
We present a dual-trap optical tweezers setup which directly measures forces using linear momentum conservation. The setup uses a counter-propagating geometry, which allows momentum measurement on each ...
Improving signal/noise resolution in single-molecule experiments using molecular constructs with short handles
(Elsevier, 2011)
We investigate unfolding/folding force kinetics in DNA hairpins exhibiting two and three states with newly designed short dsDNA handles (29 bp) using optical tweezers. We show how the higher stiffness ...
Dynamic force spectroscopy of DNA hairpins: II. Irreversibility and dissipation
(IOP Publishing, 2009)
We investigate irreversibility and dissipation in single molecules that cooperatively fold/unfold in a two-state manner under the action of mechanical force. We apply path thermodynamics to derive ...
Dynamic force spectroscopy of DNA hairpins: I. Force kinetics and free energy landscapes
(IOP Publishing, 2009)
We investigate the thermodynamics and kinetics of DNA hairpins that fold/unfold under the action of applied mechanical force. We introduce the concept of the molecular free energy landscape and derive ...
Single-molecule stochastic resonance
(American Physical Society, 2012)
Stochastic resonance (SR) is a well-known phenomenon in dynamical systems. It consists of the amplification and optimization of the response of a system assisted by stochastic (random or probabilistic) ...
Statistical properties of metastable intermediates in DNA unzipping
(American Physical Society, 2009)
We unzip DNA molecules using optical tweezers and determine the sizes of the cooperatively unzipping and zipping regions separating consecutive metastable intermediates along the unzipping pathway. Sizes ...