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Mostrando ítems 11-20 de 21
Engineering a genome-reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo
(EMBO Press, 2021)
Bacteria present a promising delivery system for treating human diseases. Here, we engineered the genome-reduced human lung pathogen Mycoplasma pneumoniae as a live biotherapeutic to treat biofilm-associated ...
Chronic full-band recordings with graphene microtransistors as neural interfaces for discrimination of brain states
(Royal Society of Chemistry, 2024)
Brain states such as sleep, anesthesia, wakefulness, or coma are characterized by specific patterns of cortical activity dynamics, from local circuits to full-brain emergent properties. We previously ...
Derivation of nearest-neighbor DNA parameters in magnesium from single molecule experiments
(Oxford University Press, 2017)
DNA hybridization is an essential molecular reaction in biology with many applications. The nearest-neighbor (NN) model for nucleic acids predicts DNA thermodynamics using energy values for the different ...
Measurement of work in single-molecule pulling experiments
(AIP Publishing, 2009)
A main goal of single-molecule experiments is to evaluate equilibrium free energy differences by applying fluctuation relations to repeated work measurements along irreversible processes. We quantify ...
Single-molecule derivation of salt dependent base-pair free energies in DNA
(National Academy of Sciences, 2010)
Accurate knowledge of the thermodynamic properties of nucleic acids is crucial to predicting their structure and stability. To date most measurements of base-pair free energies in DNA are obtained in ...
Dynamic force spectroscopy of DNA hairpins: II. Irreversibility and dissipation
(IOP Publishing, 2009)
We investigate irreversibility and dissipation in single molecules that cooperatively fold/unfold in a two-state manner under the action of mechanical force. We apply path thermodynamics to derive ...
Dynamic force spectroscopy of DNA hairpins: I. Force kinetics and free energy landscapes
(IOP Publishing, 2009)
We investigate the thermodynamics and kinetics of DNA hairpins that fold/unfold under the action of applied mechanical force. We introduce the concept of the molecular free energy landscape and derive ...
Investigating the thermodynamics of small biosystems with optical tweezers
(Elsevier, 2010)
We present two examples of how single-molecule experimental techniques applied to biological systems can give insight into problems within the scope of equilibrium and nonequilibrium mesoscopic ...
2P-111 Stochastic resonance in DNA hairpins(The 46th Annual Meeting of the Biophysical Society of Japan)
(The Biophysical Society of Japan, 2008)
Statistical properties of metastable intermediates in DNA unzipping
(American Physical Society, 2009)
We unzip DNA molecules using optical tweezers and determine the sizes of the cooperatively unzipping and zipping regions separating consecutive metastable intermediates along the unzipping pathway. Sizes ...