Unravelling the encapsulation of DNA and other biomolecules in HAp microcalcifications of human breast cancer tissues by raman imaging
Autor/a
Marro, Monica
Rodríguez-Rivero, Anna M.
Araujo-Andrade, Cuauhtémoc
Fernández-Figueras, María-Teresa
Pérez-Roca, Laia
Castellà, Eva
Navinés, Jordi
Mariscal, Antonio
Julián, Joan Francesc
Turon, Pau
Loza-Alvarez, Pablo
Data de publicació
2021ISSN
2072-6694
Resum
Microcalcifications are detected through mammography screening and, depending on their morphology and distribution (BI-RADS classification), they can be considered one of the first indicators of suspicious cancer lesions. However, the formation of hydroxyapatite (HAp) calcifications and their relationship with malignancy remains unknown. In this work, we report the most detailed three-dimensional biochemical analysis of breast cancer microcalcifications to date, combining 3D Raman spectroscopy imaging and advanced multivariate analysis in order to investigate in depth the molecular composition of HAp calcifications found in 26 breast cancer tissue biopsies. We demonstrate that DNA has been naturally adsorbed and encapsulated inside HAp microcalcifications. Furthermore, we also show the encapsulation of other relevant biomolecules in HAp calcifications, such as lipids, proteins, cytochrome C and polysaccharides. The demonstration of natural DNA biomineralization, particularly in the tumor microenvironment, represents an unprecedented advance in the field, as it can pave the way to understanding the role of HAp in malignant tissues.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
61 - Medicina
Paraules clau
Microcalcificacions
Mineralització de l’ADN
ADN
Càncer de pulmó
Microambient tumoral
Espectroscòpia
Microcalcificaciones
Mineralización del ADN
ADN
Cáncer de pulmón
Microambiente tumoral
Espectroscopia
Microcalcifications
DNA mineralization
DNA
Lung cancer
Tumor microenvironment
Spectroscopy
Pàgines
17
Publicat per
MDPI
Col·lecció
13; 11
Publicat a
Cancers
Citació
Marro, Monica; Rodríguez-Rivero, Anna M.; Araujo-Andrade, Cuauhtémoc [et al.]. Unravelling the encapsulation of DNA and other biomolecules in HAp microcalcifications of human breast cancer tissues by raman imaging. Cancers, 2021, 13(11), 2658. Disponible en: <https://www.mdpi.com/2072-6694/13/11/2658>. Fecha de acceso: 10 jun. 2021. DOI: 10.3390/cancers13112658
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Ciències de la Salut [740]
Drets
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com https://creativecommons.org/licenses/by/4.0/