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dc.contributor.authorFanlo-Maresma, Marta
dc.contributor.authorCandás-Estébanez, Beatriz
dc.contributor.authorEsteve-Luque, Virginia
dc.contributor.authorPadró-Miquel, Ariadna
dc.contributor.authorEscrihuela-Vidal, Francesc
dc.contributor.authorCarratini-Moraes, Monica
dc.contributor.authorCorbella, Emili
dc.contributor.authorCorbella Virós, Xavier
dc.contributor.authorPintó, Xavier
dc.date.accessioned2021-06-07T13:55:39Z
dc.date.available2021-06-07T13:55:39Z
dc.date.issued2021
dc.identifier.citationFanlo-Maresma, Marta; Candás-Estébanez, Beatriz; Esteve-Luque, Virginia [et al.]. Asymptomatic carotid atherosclerosis cardiovascular risk factors and common hypertriglyceridemia genetic variants in patients with systemic erythematosus lupus. Journal of Clinical Medicine, 2021, 10(10), 2218. Disponible en: <https://www.mdpi.com/2077-0383/10/10/2218>. Fecha de acceso: 7 jun. 2021. DOI: 10.3390/jcm10102218ca
dc.identifier.issn2077-0383ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/2602
dc.description.abstractSLE is associated with increased cardiovascular risk. The objective of this study was to determine the prevalence of asymptomatic carotid atherosclerosis to analyze its relationship with dyslipidemia and related genetic factors in a population of patients with SLE. Seventy-one SLE female patients were recruited. Carotid ultrasound, laboratory profiles, and genetic analysis of the ZPR1, APOA5, and GCKR genes were performed. SLE patients were divided into two groups according to the presence or absence of carotid plaques. Patients with carotid plaque had higher plasma TG (1.5 vs. 0.9 mmol/L, p = 0.001), Non-HDL-C (3.5 vs. 3.1 mmol/L, p = 0.025), and apoB concentrations (1.0 vs. 0.9 g/L, p = 0.010) and a higher prevalence of hypertension (80 vs. 37.5%, p = 0.003) than patients without carotid plaque. The GCKR C-allele was present in 83.3% and 16.7% (p = 0.047) of patients with and without carotid plaque, respectively. The GCKR CC genotype (OR = 0.026; 95% CI: 0.001 to 0.473, p = 0.014), an increase of 1 mmol/L in TG concentrations (OR = 12.550; 95% CI: 1.703 to 92.475, p = 0.013) and to be hypertensive (OR = 9.691; 95% CI: 1.703 to 84.874, p = 0.040) were independently associated with carotid atherosclerosis. In summary, plasma TG concentrations, CGKR CC homozygosity, and hypertension are independent predictors of carotid atherosclerosis in women with SLE.en
dc.format.extent12ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofJournal of Clinical Medicineca
dc.relation.ispartofseries10;10
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.otherTriglicèridsca
dc.subject.otherAterosclerosica
dc.subject.otherLupus eritematós sistèmicca
dc.subject.otherRisc cardiovascular
dc.subject.otherAterosclerosi caròtida asimptomàtica
dc.subject.otherHipertensió
dc.subject.otherDones -- Salut i higiene
dc.subject.otherTriglicéridoses
dc.subject.otherAterosclerosises
dc.subject.otherLupus eritematoso sistémicoes
dc.subject.otherRiesgo cardiovasculares
dc.subject.otherAterosclerosis carótida asintomáticaes
dc.subject.otherHipertensiónes
dc.subject.otherMujeres -- Salud e higienees
dc.subject.otherTriglyceridesen
dc.subject.otherAtherosclerosisen
dc.subject.otherSystemic lupus erythematosusen
dc.subject.otherCardiovascular risken
dc.subject.otherAsymptomatic carotid atherosclerosisen
dc.subject.otherHypertensionen
dc.subject.otherWomen - Health and hygieneen
dc.titleAsymptomatic carotid atherosclerosis cardiovascular risk factors and common hypertriglyceridemia genetic variants in patients with systemic erythematosus lupusen
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc61ca
dc.subject.udc616.1ca
dc.identifier.doihttps://dx.doi.org/10.3390/jcm10102218ca


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com https://creativecommons.org/licenses/by/4.0/
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