Antibacterial approaches in tissue engineering using metal ions and nanoparticles: from mechanisms to applications
Autor/a
Godoy Gallardo, Maria
Eckhard, Ulrich
Delgado, Luis M.
de Roo Puente, Yolanda J.D.
Hoyos Nogués, Mireia
Gil Mur, Francisco Javier
Pérez Antoñanzas, Roman
Fecha de publicación
2021-12ISSN
2452-199X
Resumen
Bacterial infection of implanted scaffolds may have fatal consequences and, in combination with the emergence of multidrug bacterial resistance, the development of advanced antibacterial biomaterials and constructs is of great interest. Since decades ago, metals and their ions had been used to minimize bacterial infection risk and, more recently, metal-based nanomaterials, with improved antimicrobial properties, have been advocated as a novel and tunable alternative. A comprehensive review is provided on how metal ions and ion nanoparticles have the potential to decrease or eliminate unwanted bacteria. Antibacterial mechanisms such as oxidative stress induction, ion release and disruption of biomolecules are currently well accepted. However, the exact antimicrobial mechanisms of the discussed metal compounds remain poorly understood. The combination of different metal ions and surface decorations of nanoparticles will lead to synergistic effects and improved microbial killing, and allow to mitigate potential side effects to the host. Starting with a general overview of antibacterial mechanisms, we subsequently focus on specific metal ions such as silver, zinc, copper, iron and gold, and outline their distinct modes of action. Finally, we discuss the use of these metal ions and nanoparticles in tissue engineering to prevent implant failure.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
61 - Medicina
615 - Farmacología. Terapéutica. Toxicología. Radiología
Palabras clave
Malalties bacterianes
Resistència als medicaments
Materials biomèdics
Bacteris
Ions
Biomolècules
Teixits
Regeneració (Biologia)
Ions metàl·lics
Nanopartícules
Enfermedades bacterianas
Resistencia a los medicamentos
Materiales biomédicos
Bacterias
Iones
Biomoléculas
Tejidos
Regeneración (Biología)
Iones metálicos
Nanopartículas
Bacterial diseases
Drug resistance
Biomedical materials
Bacteria
Ions
Biomolecules
Tissues
Regeneration (Biology)
Metal ions
Nanoparticles
Páginas
21
Publicado por
Elsevier
Colección
6; 12
Publicado en
Bioactive Materials
Citación
Godoy-Gallardo, Maria; Eckhard, Ulrich; Delgado, Luis M. [et al.]. Antibacterial approaches in tissue engineering using metal ions and nanoparticles: from mechanisms to applications. Bioactive Materials, 2021, 6(12), p. 4470-4490. Disponible en: <https://www.sciencedirect.com/science/article/pii/S2452199X21002024>. Fecha de acceso: 28 may. 2021. DOI: 10.1016/j.bioactmat.2021.04.033
Número del acuerdo de la subvención
info:eu-repo/grantAgreement/EC/H2020/801370
info:eu-repo/grantAgreement/ES/2PE/RYC2018-025977-I
info:eu-repo/grantAgreement/ES/2PE/RTI2018-096088-J-100
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