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Delayed cerebral vasculopathy in pneumococcal meningitis: epidemiology and clinical outcome. A cohort study
dc.contributor.author | Boix-Palop, Lucía | |
dc.contributor.author | Fernández, Tamara | |
dc.contributor.author | Pelegrín, Iván | |
dc.contributor.author | Obradors, Meritxell | |
dc.contributor.author | García-Roulston, Kevin | |
dc.contributor.author | Xercavins Valls, Mariona | |
dc.contributor.author | García-Somoza, Dolors | |
dc.contributor.author | Ardanuy, Carmen | |
dc.contributor.author | Grau, Javier | |
dc.contributor.author | Calbo Sebastián, Esther | |
dc.contributor.author | Cabellos, Carmen | |
dc.date.accessioned | 2021-05-13T15:28:26Z | |
dc.date.available | 2021-05-13T15:28:26Z | |
dc.date.issued | 2020-08 | |
dc.identifier.citation | Boix-Palop, Lucía; Fernández, Tamara; Pelegrín, Iván [et al.]. Delayed cerebral vasculopathy in pneumococcal meningitis: epidemiology and clinical outcome. A cohort study. International Journal of Infectious Diseases, 2020, 97, p. 283-289. Disponible en: <https://www.sciencedirect.com/science/article/pii/S1201971220304409?via%3Dihub>. Fecha de acceso: 13 may. 2021. DOI: 10.1016/j.ijid.2020.06.005 | ca |
dc.identifier.issn | 1201-9712 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/2537 | |
dc.description.abstract | Background: To describe the prevalence, clinical characteristics, impact of systemic steroids exposure and outcomes of delayed cerebral vasculopathy (DCV) in a cohort of adult patients with pneumococcal meningitis (PM). Methods: Observational retrospective multicenter study including all episodes of PM from January 2002 to December 2015. DCV was defined as proven/probable/possible based upon clinical criteria and pathological-radiological findings. DCV-patients and non-DCV-patients were compared by univariate analysis. Results: 162 PM episodes were included. Seventeen (10.5%) DCV-patients were identified (15 possible, 2 probable). At admission, DCV-patients had a longer duration of symptoms (>2 days in 58% vs. 25.5% (p 0.04)), more coma (52.9% vs. 21.4% (p 0.03)), lower median CSF WBC-count (243 cells/uL vs. 2673 cells/uL (p 0.001)) and a higher proportion of positive CSF Gram stain (94.1% vs. 71% (p 0.07)). Median length of stay was 49 vs. 15 days (p 0.001), ICU admission was 85.7% vs. 49.5% (p 0.01) and unfavorable outcome was found in 70.6% vs. 23.8% (p 0.001). DCV appeared 1-8 days after having completed adjunctive dexamethasone treatment (median 2,5, IQR = 1.5-5). Conclusions: One tenth of the PM developed DCV. DCV-patients had a longer duration of illness, were more severely ill, had a higher bacterial load at admission and had a more complicated course. Less than one third of cases recovered without disabilities. The role of corticosteroids in DCV remains to be established. | en |
dc.format.extent | 7 | ca |
dc.language.iso | eng | ca |
dc.publisher | Elsevier | ca |
dc.relation.ispartof | International Journal of Infectious Diseases | ca |
dc.relation.ispartofseries | 97; | |
dc.rights | © 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.other | Meningitis | ca |
dc.subject.other | Cervell -- Malalties | ca |
dc.subject.other | Pneumococs | ca |
dc.subject.other | Bacteries | ca |
dc.subject.other | Meningitis | es |
dc.subject.other | Cerebro -- Enfermedades | es |
dc.subject.other | Streptococcus pneumoniae | es |
dc.subject.other | Bacterias | es |
dc.subject.other | Meningitis | en |
dc.subject.other | Brain -- Diseases | en |
dc.subject.other | Pneumococcus | en |
dc.subject.other | Bacteria | en |
dc.title | Delayed cerebral vasculopathy in pneumococcal meningitis: epidemiology and clinical outcome. A cohort study | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.subject.udc | 616.8 | ca |
dc.identifier.doi | https://dx.doi.org/10.1016/j.ijid.2020.06.005 | ca |
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