Bullous henoch-schönlein purpura: a case series
Author
Paloni, Giulia
Silecchia, Valeria
Berti, Irene
Tagarelli, Arianna
Mazzoni, Elisa
Lambertini, Andrea
Valerio, Enrico
Grimalt Santacana, Ramon
Cutrone, Mario
Publication date
2019-12ISSN
2413-8223
Abstract
Henoch-Schönlein purpura (HSP) represents the most common vasculitis in children. Typically, HSP manifests with palpable purpura and edema, usually following an urticarial or erythematous maculopapular eruption. Bullous HSP represents an uncommon presentation of “classic” HSP, exhibited by only 2% of affected children. We here present three cases of bullous HSP. This variant seems due to an excess of production of neutrophilic matrix metalloproteinase-9, a lytic enzyme that degrades basement membrane components, eventually leading to dermoepidermal detachment and blister formation. Notably, American College of Rheumatology (ACR), Paediatric Rheumatology European Society (PRES), European League against Rheumatism (EULAR), and Paediatric Rheumatology INternational Trials Organization (PRINTO) do not encompass blisters and/or bullae into HSP classification criteria. Outcome of bullous HSP does not differ from “classic” purpuric HSP. The former, however, demands special care measures: local pain control, topic antibiotic therapy, and protective dressings over areas of open or blistered skin.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Dermatologia
Pediatria
Vasculitis
Ferides i lesions
Dermatología
Pediatría
Vasculitis
Heridas y lesiones
Dermatology
Pediatrics
Vasculitis
Wounds and injuries
Pages
4
Publisher
ACT Publishing Group Limited
Collection
4; 2
Is part of
Journal of Respiratory Research
Citation
Paloni, Giulia; Silecchia, Valeria; Berti, Irene [et al.]. Bullous henoch-schönlein purpura: a case series. Journal of Respiratory Research, 2019, 4(2), p. 191-184. Disponible en: <http://www.ghrnet.org/index.php/jdr/article/view/2733>. Fecha de acceso: 5 may. 2021. DOI: :10.17554/j.issn.2413-8223.2019.04.46-7
This item appears in the following Collection(s)
- Ciències de la Salut [740]
Rights
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work noncommercially, and license their derivative works on different terms, provided the original work is properly cited and the use is noncommercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc/4.0/