The return of malonyl-CoA to the brain: cognition and other stories
Author
Fadó Andrés, Rut
Rodríguez-Rodríguez, Rosalía
Casals i Farré, Núria
Publication date
2021-01ISSN
0163-7827
Abstract
Nutrients, hormones and the energy sensor AMP-activated protein kinase (AMPK) tightly regulate the intracel-lular levels of the metabolic intermediary malonyl-CoA, which is a precursor of fatty acid synthesis and a negative regulator of fatty acid oxidation. In the brain, the involvement of malonyl-CoA in the control of food intake and energy homeostasis has been known for decades. However, recent data uncover a new role in cognition and brain development. The sensing of malonyl-CoA by carnitine palmitoyltransferase 1 (CPT1) pro-teins regulates a variety of functions, such as the fate of neuronal stem cell precursors, the motility of lysosomes in developing axons, the trafficking of glutamate receptors to the neuron surface (necessary for proper synaptic function) and the metabolic coupling between astrocytes and neurons. We discuss the relevance of those recent findings evidencing how nutrients and metabolic disorders impact cognition. We also enumerate all nutritional and hormonal conditions that are known to regulate malonyl-CoA levels in the brain, reflect on protein malo-nylation as a new post-translational modification, and give a reasoned vision of the opportunities and challenges that future research in the field could address.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Cognició
Cervell
Metabolisme
Cognición
Cerebro
Metabolismo
Cognition
Brain
Metabolism
Pages
11
Publisher
Elsevier
Collection
81;
Is part of
Progress in Lipid Research
Citation
Fadó, Rut; Rodríguez-Rodríguez, Rosalía; Casals, Núria. The return of malonyl-CoA to the brain: cognition and other stories. Progress in Lipid Research, 2021, 81, [p. 1-11]. Disponible en: <https://www.sciencedirect.com/science/article/pii/S0163782720300515>. Fecha de acceso: 12 ene. 2021. DOI: 10.1016/j.plipres.2020.101071
Grant agreement number
info:eu-repo/grantAgreement/ES/2PE/SAF2017-83813- C3-3-R
This item appears in the following Collection(s)
- Ciències de la Salut [729]
Rights
© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/