Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study
Autor/a
Garay, Alberto
Tapia, Javier
Anguita, Manuel
Formiga, Francesc
Almenar, Luis
Crespo-Leiro, María G.
Manzano, Luis
Muñiz, Javier
Chaves, José
De Frutos, Trinidad
Moliner, Pedro
Corbella Virós, Xavier
Enjuanes-Grau, Cristina
Comin-Colet, Josep
VIDA-IC Multicenter Study Investigators
Fecha de publicación
2020-08-31ISSN
2077-0383
Resumen
Previous studies have shown that heart failure is associated with worse health-related quality of life (HRQoL). The existence of differences according to gender remains controversial. We studied 1028 consecutive outpatients with heart failure and reduced ejection fraction (HFrEF) from a multicentre cross-sectional descriptive study across Spain that assessed HRQoL using two questionnaires (KCCQ, Kansas City Cardiomyopathy Questionnaire; and EQ-5D, EuroQoL 5 dimensions). The primary objective of the study was to describe differences in HRQoL between men and women in global scores and domains of health status of patients and explore gender differences and its interactions with heart failure related factors. In adjusted analysis women had lower scores in KCCQ overall summary scores when compared to men denoting worse HRQoL (54.7 ± 1.3 vs. 62.7 ± 0.8, p < 0.0001), and specifically got lower score in domains of symptom frequency, symptoms burden, physical limitation, quality of life and social limitation. No differences were found in domains of symptom stability and self-efficacy. Women also had lower scores on all items of EQ-5D (EQ-5D index 0.58 ± 0.01 vs. 0.67 ± 0.01, p < 0.0001). Finally, we analyzed interaction between gender and different clinical determinants regarding the presence of limitations in the 5Q-5D and overall summary score of KCCQ. Interestingly, there was no statistical significance for interaction for any variable. In conclusion, women with HFrEF have worse HRQoL compared to men. These differences do not appear to be mediated by clinical or biological factors classically associated with HRQoL nor with heart failure severity.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
61 - Medicina
616.1 - Patología del sistema circulatorio, de los vasos sanguíneos. Transtornos cardiovasculares
Palabras clave
Cardiologia
Insuficiència cardíaca
Qualitat de vida
Cardiología
Insuficiencia cardíaca
Calidad de vida
Cardiology
Heart failure
Life, Quality of
Páginas
14
Publicado por
MDPI
Colección
9; 9
Publicado en
Journal of Clinical Medicine
Citación
Garay, Alberto; Tapia, Javier; Anguita, Manuel [et al.]. Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study. Journal of Clinical Medicine, 2020, 9(9), p. 1-14. Disponible en: <https://www.mdpi.com/2077-0383/9/9/2825>. Fecha de acceso: 27 nov. 2020. DOI: 10.3390/jcm9092825.
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Derechos
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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