Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study
Author
Garay, Alberto
Tapia, Javier
Anguita, Manuel
Formiga, Francesc
Almenar, Luis
Crespo-Leiro, María G.
Manzano, Luis
Muñiz, Javier
Chaves, José
De Frutos, Trinidad
Moliner, Pedro
Corbella Virós, Xavier
Enjuanes-Grau, Cristina
Comin-Colet, Josep
VIDA-IC Multicenter Study Investigators
Publication date
2020-08-31ISSN
2077-0383
Abstract
Previous studies have shown that heart failure is associated with worse health-related quality of life (HRQoL). The existence of differences according to gender remains controversial. We studied 1028 consecutive outpatients with heart failure and reduced ejection fraction (HFrEF) from a multicentre cross-sectional descriptive study across Spain that assessed HRQoL using two questionnaires (KCCQ, Kansas City Cardiomyopathy Questionnaire; and EQ-5D, EuroQoL 5 dimensions). The primary objective of the study was to describe differences in HRQoL between men and women in global scores and domains of health status of patients and explore gender differences and its interactions with heart failure related factors. In adjusted analysis women had lower scores in KCCQ overall summary scores when compared to men denoting worse HRQoL (54.7 ± 1.3 vs. 62.7 ± 0.8, p < 0.0001), and specifically got lower score in domains of symptom frequency, symptoms burden, physical limitation, quality of life and social limitation. No differences were found in domains of symptom stability and self-efficacy. Women also had lower scores on all items of EQ-5D (EQ-5D index 0.58 ± 0.01 vs. 0.67 ± 0.01, p < 0.0001). Finally, we analyzed interaction between gender and different clinical determinants regarding the presence of limitations in the 5Q-5D and overall summary score of KCCQ. Interestingly, there was no statistical significance for interaction for any variable. In conclusion, women with HFrEF have worse HRQoL compared to men. These differences do not appear to be mediated by clinical or biological factors classically associated with HRQoL nor with heart failure severity.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
616.1 - Pathology of the circulatory system, blood vessels. Cardiovascular complaints
Keywords
Cardiologia
Insuficiència cardíaca
Qualitat de vida
Cardiología
Insuficiencia cardíaca
Calidad de vida
Cardiology
Heart failure
Life, Quality of
Pages
14
Publisher
MDPI
Collection
9; 9
Is part of
Journal of Clinical Medicine
Citation
Garay, Alberto; Tapia, Javier; Anguita, Manuel [et al.]. Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study. Journal of Clinical Medicine, 2020, 9(9), p. 1-14. Disponible en: <https://www.mdpi.com/2077-0383/9/9/2825>. Fecha de acceso: 27 nov. 2020. DOI: 10.3390/jcm9092825.
This item appears in the following Collection(s)
- Ciències de la Salut [740]
Rights
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0