The quantitative changes in the yeast Hsp70 and Hsp90 interactomes upon DNA damage
Autor/a
Truman, Andrew W.
Kristjansdottir, Kolbrun
Wolfgeher, Donald
Ricco Pacheco, Natalia
Mayampurath, Anoop
Volchenboum, Samuel L.
Clotet Erra, Josep
Kron, Stephen J.
Fecha de publicación
2015-03ISSN
2352-3409
Resumen
The molecular chaperones Hsp70 and Hsp90 participate in many important cellular processes, including how cells respond to DNA damage. Here we show the results of applied quantitative affinity-purification mass spectrometry (AP-MS) proteomics to understand the protein network through which Hsp70 and Hsp90 exert their effects on the DNA damage response (DDR). We characterized the interactomes of the yeast Hsp70 isoform Ssa1 and Hsp90 isoform Hsp82 before and after exposure to methyl methanesulfonate. We identified 256 chaperone interactors, 146 of which are novel. Although the majority of chaperone interaction remained constant under DNA damage, 5 proteins (Coq5, Ast1, Cys3, Ydr210c and Rnr4) increased in interaction with Ssa1 and/or Hsp82. This data presented here are related to [1] (Truman et al., in press). The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the PRIDE partner repository (Vizcaino et al. (2013) [2]) with the dataset identifier PXD001284.
Tipo de documento
Artículo
Versión del documento
Versión aceptada
Lengua
English
Materias (CDU)
61 - Medicina
Palabras clave
ADN--Anàlisi
Molècules
Espectrometria de masses
ADN--Análisis
Moléculas
Espectrometría de masas
DNA--Analysis
Molecules
Mass spectrometry
Páginas
4
Publicado por
Elsevier
Colección
2;
Publicado en
Data in Brief
Citación
Truman, Andrew W.; Kristjansdottir, Kolbrun; Wolfgeher, Donald [et al.]. The quantitative changes in the yeast Hsp70 and Hsp90 interactomes upon DNA damage. Data in Brief, 2015, vol. 2, p. 12-15. Disponible en: <https://www.sciencedirect.com/science/article/pii/S2352340914000249?via%3Dihub#t0005>. Fecha de acceso: 4 ene. 2020. DOI: 10.1016/j.dib.2014.10.006.
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Derechos
© 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
Excepto si se señala otra cosa, la licencia del ítem se describe como http://creativecommons.org/licenses/by/3.0/