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K-means clustering identifies diverse clinical phenotypes in COVID-19 patients: implications for mortality risks and remdesivir impact
(Springer Nature, 2024)
Introduction: The impact of remdesivir on mortality in patients with COVID-19 is still controversial. We aimed to identify clinical phenotype clusters of COVID-19 hospitalized patients with highest ...
Consumo de tabaco en Costa Rica: ¿está el país preparado para el “fin del juego”?
(Organización Panamericana de la Salud, 2024)
El consumo de tabaco es, todavía, uno de los principales factores de riesgo de morbilidad y mortalidad en todo el mundo. Sin embargo, las acciones realizadas para el control del tabaco en las últimas ...
CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation
(Wiley, 2023)
Cyclin-dependent kinases (CDKs), together with their cyclin partners, are the master cell cycle regulators. Remarkably, the cyclin family was extended to include atypical cyclins, characterized by ...
Efficacy of aerobic exercise on widespread pain sensitization in patients with temporomandibular disorders: a preliminary randomized controlled study
(MDPI, 2024)
Myogenic temporomandibular disorders (TMDs) are commonly associated with pain sensitization (PS), manifesting decreased local and distal pressure pain thresholds (PPTs). Aerobic exercise (AE) has shown ...
The use of simulation in nursing education programs: a cross-sectional interuniversity study
(Hindawi, 2024)
Background. Simulation-based education has been incorporated into nursing curricula as an educational strategy. However, its implementation has not yet been standardized in different regions. Purpose. ...
Comprehensive and quantitative analysis of G1 cyclins. A tool for studying the cell cycle
(Public Library of Science, 2019-06-25)
In eukaryotes, the cell cycle is driven by the actions of several cyclin dependent kinases (CDKs) and an array of regulatory proteins called cyclins, due to the cyclical expression patterns of the latter. ...
Perception of quality of care of patients with potentially severe diseases evaluated at a distinct quick diagnostic delivery model: a cross-sectional study
(Springer Nature, 2015-09-30)
Background: Although hospital-based outpatient quick diagnosis units (QDU) are an increasingly recognized cost-effective alternative to hospitalization for the diagnosis of potentially serious diseases, ...
Educational climate perception by preclinical and clinical medical students in five Spanish medical schools
(IJME, 2015-06-08)
Objectives: The purpose of this study was to investigate student’s perceptions of Educational Climate (EC) in Spanish medical schools, comparing various aspects of EC between the 2nd (preclinical) and ...
Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice
(American Society for Biochemistry and Molecular Biology, 2019-07)
The endocannabinoid (eCB) system regulates energy homeostasis and is linked to obesity development. However, the exact dynamic and regulation of eCBs in the hypothalamus during obesity progression remain ...
Evidence of functional declining and global comorbidity measured at baseline proved to be the strongest predictors for long-term death in elderly community residents aged 85 years: a 5-year follow-up evaluation, the OCTABAIX study
(Dove Press, 2016-04-18)
Objective: To investigate the predictive value of functional impairment, chronic conditions, and laboratory biomarkers of aging for predicting 5-year mortality in the elderly aged 85 years. Methods: ...