Browsing Ciències de la Salut by Author "Wright, Roni H.G."

Now showing items 1-8 of 8

    • 90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome 

      Beato, Miguel; Wright, Roni H.G.; Le Dily, François (Journal of Molecular Endocrinology, 2020)
      Gene regulation by steroid hormones has been at the forefront in elucidating the intricacies of transcriptional regulation in eukaryotes ever since the discovery by Karlson and Clever that the insect ...

    • Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation 

      Le Dily, François; Bau, Davide; Pohl, Andy; Vicent, Guillermo P.; Serra, Francois; Soronellas, Daniel; Castellano, Giancarlo; Wright, Roni H.G.; Ballare, Cecilia; Filion, Guillaume; Marti-Renom, Marc A.; Beato, Miguel (Genes & Development, 2014)
      The human genome is segmented into topologically associating domains (TADs), but the role of this conserved organization during transient changes in gene expression is not known. Here we describe the ...

    • Expression of oncogenic drivers in 3D cell culture depends on nuclear ATP synthesis by NUDT5 

      Pickup, Katherine E.; Pardow, Felicitas; Carbonell-Caballero, José; Lioutas, Antonios; Villanueva-Cañas, José Luis; Wright, Roni H.G.; Beato, Miguel (Cancers, 2019)
      The growth of cancer cells as oncospheres in three-dimensional (3D) culture provides a robust cell model for understanding cancer progression, as well as for early drug discovery and validation. We have ...

    • Hormone-control regions mediate steroid receptor–dependent genome organization 

      Le Dily, François; Vidal, Enrique; Cuartero, Yasmina; Quilez Oliete, Javier; Nacht, A. Silvina; Vicent, Guillermo P.; Carbonell-Caballero, José; Sharma, Priyanka; Villanueva-Cañas, José Luis; Ferrari, Roberto; De Llobet, Lara Isabel; Verde, Gaetano; Wright, Roni H.G.; Beato, Miguel (Genome Research, 2019)
      In breast cancer cells, some topologically associating domains (TADs) behave as hormonal gene regulation units, within which gene transcription is coordinately regulated in response to steroid hormones. ...

    • MyoD induces ARTD1 and nucleoplasmic poly-ADP-ribosylation during fibroblast to myoblast transdifferentiation 

      Bisceglie, Lavinia; Hopp, Ann-Katrin; Gunasekera, Kapila; Wright, Roni H.G.; Le Dily, François; Vidal, Enrique; Dall'Agnese, Alessandra; Caputo, Luca; Nicoletti, Chiara; Puri, Pier Lorenzo; Beato, Miguel; Hottiger, Michael O. (iScience, 2021)
      While protein ADP-ribosylation was reported to regulate differentiation and dedifferentiation, it has so far not been studied during transdifferentiation. Here, we found that MyoD-induced transdifferentiation ...

    • Role of the NUDT enzymes in breast cancer 

      Wright, Roni H.G.; Beato, Miguel (International Journal of Molecular Sciences, 2021)
      Despite global research efforts, breast cancer remains the leading cause of cancer death in women worldwide. The majority of these deaths are due to metastasis occurring years after the initial treatment ...

    • Signalling network of breast cancer cells in response to progesterone 

      Wright, Roni H.G.; Vastolo, Viviana; Quilez Oliete, Javier; Carbonell-Caballero, José; Beato, Miguel (BioRxiv, 2020)
      Breast cancer cells enter into the cell cycle following progestin exposure by the activation of signalling cascades involving a plethora of enzymes, transcription factors and co-factors that transmit ...

    • Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells 

      Page, Brent D.G.; Valerie, Nicholas C.K.; Wright, Roni H.G.; Wallner, Olov; Isaksson, Rebecka; Carter, Megan; Rudd, Sean G.; Loseva, Olga; Jemth, Ann-Sofie; Almlöf, Ingrid; Font-Mateu, Jofre; Llona-Minguez, Sabin; Baranczewski, Pawel; Jeppsson, Fredrik; Homan, Evert; Almqvist, Helena; Axelsson, Hanna; Regmi, Shruti; Gustavsson, Anna-Lena; Lundbäck, Thomas; Scobie, Martin; Strömberg, Kia; Stenmark, Pål; Beato, Miguel; Helleday, Thomas (Nature Communications, 2018)
      With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in ADP-ribose and 8-oxo-guanine ...