Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast
Autor/a
Martínez-Láinez, Joan M.
Moreno, David F.
Parisi, Eva
Clotet Erra, Josep
Aldea Malo, Martí
Fecha de publicación
2018-08-06ISSN
1544-9173
Resumen
Cell size scales with ploidy in a great range of eukaryotes, but the underlying mechanisms
remain unknown. Using various orthogonal single-cell approaches, we show that cell size
increases linearly with centromere (CEN) copy number in budding yeast. This effect is due
to a G1 delay mediated by increased degradation of Cln3, the most upstream G1 cyclin acting
at Start, and specific centromeric signaling proteins, namely Mad3 and Bub3. Mad3
binds both Cln3 and Cdc4, the adaptor component of the Skp1/Cul1/F-box (SCF) complex
that targets Cln3 for degradation, these interactions being essential for the CEN-dosage
dependent effects on cell size. Our results reveal a pathway that modulates cell size as a
function of CEN number, and we speculate that, in cooperation with other CEN-independent
mechanisms, it could assist the cell to attain efficient mass/ploidy ratios
Tipo de documento
Artículo
Versión del documento
Versión aceptada
Lengua
English
Materias (CDU)
61 - Medicina
Palabras clave
Genomes
Genomas
Cells
Cèl·lules
Células
Páginas
13
Publicado por
Public Library of Science
Colección
16; 8
Publicado en
PLoS Biology
Citación
Martínez-Láinez, Joan M.; Moreno, David F.; Parisi, Eva; Clotet, Josep; Aldea Malo, Martí. «Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast». PLoS Biology, 2018, vol. 16, núm. 8, art. e2005388. Disponible en: <https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005388>. Fecha de acceso: 24 oct. 2019. DOI: 10.1371/journal.pbio.2005388
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