The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle
Autor/a
Ferrezuelo, Francisco
Colomina, Neus
Futcher, Bruce
Aldea Malo, Martí
Data de publicació
2010-06-23ISSN
1474-760X
Resum
Background: The G1-to-S transition of the cell cycle in the yeast Saccharomyces cerevisiae involves an extensive
transcriptional program driven by transcription factors SBF (Swi4-Swi6) and MBF (Mbp1-Swi6). Activation of these
factors ultimately depends on the G1 cyclin Cln3.
Results: To determine the transcriptional targets of Cln3 and their dependence on SBF or MBF, we first have used DNA
microarrays to interrogate gene expression upon Cln3 overexpression in synchronized cultures of strains lacking
components of SBF and/or MBF. Secondly, we have integrated this expression dataset together with other
heterogeneous data sources into a single probabilistic model based on Bayesian statistics. Our analysis has produced
more than 200 transcription factor-target assignments, validated by ChIP assays and by functional enrichment. Our
predictions show higher internal coherence and predictive power than previous classifications. Our results support a
model whereby SBF and MBF may be differentially activated by Cln3.
Conclusions: Integration of heterogeneous genome-wide datasets is key to building accurate transcriptional
networks. By such integration, we provide here a reliable transcriptional network at the G1-to-S transition in the
budding yeast cell cycle. Our results suggest that to improve the reliability of predictions we need to feed our models
with more informative experimental data.
Tipus de document
Article
Versió del document
Versió acceptada
Llengua
English
Matèries (CDU)
61 - Medicina
Paraules clau
Genomes
Genomas
ADN
DNA
Cln3
G1-to-S
Pàgines
18
Publicat per
BMC
Col·lecció
11;
Publicat a
Genome Biology
Citació
Ferrezuelo, Francisco; Colomina, Neus; Futcher, Bruce; Aldea Malo, Martí. «The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle». Genome Biology, 2010, vol. 11, art. R67. Disponible en: <https://genomebiology.biomedcentral.com/articles/10.1186/gb-2010-11-6-r67>. Fecha de acceso: 21 oct. 2019. DOI: https://doi.org/10.1186/gb-2010-11-6-r67
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