X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk
Autor/a
Fadó Andrés, Rut
Moubarak, Rana S.
Miñano Molina, Alfredo Jesús
Barneda-Zahonero, Bruna
Valero, Jorge
Saura, Carlos A.
Moran, Julio
Comella, Joan X.
Rodríguez-Álvarez, José
Data de publicació
2013-08-09ISSN
2045-2322
Resum
X-linked Inhibitor of apoptosis protein (XIAP) has been classically identified as a cell death regulator. Here,
we demonstrate a novel function of XIAP as a regulator of neurite outgrowth in neuronal cells. In PC12 cells,
XIAP overexpression prevents NGF-induced neuronal differentiation, whereas NGF treatment induces a
reduction of endogenous XIAP levels concomitant with the induction of neuronal differentiation.
Accordingly, downregulation of endogenous XIAP protein levels strongly increases neurite outgrowth in
PC12 cells as well as axonal and dendritic length in primary cortical neurons. The effects of XIAP are
mediated by the mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinases (ERKs)
pathway since blocking this pathway completely prevents the neuritogenesis mediated by XIAP
downregulation. In addition, we found that XIAP binds to cRaf and Trk receptors. Our results demonstrate
that XIAP plays a new role as a negative regulator of neurotrophin-induced neurite outgrowth and neuronal
differentiation in developing neurons.
Tipus de document
Article
Versió del document
Versió acceptada
Llengua
English
Matèries (CDU)
61 - Medicina
Paraules clau
Neurociencias
Neurociències
Neurosciences
Inhibició
Inhibition
Apoptosi
Apoptosis
Pàgines
11
Publicat per
Nature Research
Col·lecció
3;
Publicat a
Scientific Reports
Citació
Fadó Andrés, Rut; Moubarak, Rana S.; Miñano-Molina, Alfredo J.; Barneda-Zahonero, Bruna; Valero, Jorge; Saura, Carlos A.; Moran, Julio; Comella, Joan X.; Rodríguez-Álvarez, José. «X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk». Scientific Reports, 2013, vol. 3, art. 2397. Disponible en: <https://www.nature.com/articles/srep02397>. Fecha de acceso: 16 oct. 2019
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Drets
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