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Evaluation of biomarkers for studying new challenges in tobacco control
(Date of defense: 2023-12-19)El tabaquismo es reconocido a nivel global como un factor de riesgo significativo para la salud pública y una de las principales causas de muertes prevenibles. España ha implementado políticas de control ... -
CPT1C-ABHD6 interaction in hypothalamic neurons: implications for bis (monoacylglycero) phosphate metabolism and the endolysosomal system
(Date of defense: 2024-02-14)El sistema endolisosomal juga un paper crític en la funció neuronal i ha emergit com a un potencial objectiu per al tractament de diverses malalties neuronals, com els trastorns neurodegeneratius i fins ... -
Development of C75-CoA loaded polymeric micelles targeting brain CPT1A: A novel nanomedicine-based approach to fight obesity and cancer
(Date of defense: 2024-02-14)Brain lipid metabolism has a key role in many physiological processes, and its malfunction is associated with a plethora of diseases, such as obesity and glioblastoma multiforme (GBM). Carnitine palmitoyl ... -
La cronicidad en enfermedad mental: políticas y modelos de atención integrados y centrados en las personas y la comunidad
(Date of defense: 2023-12-14)La creciente prevalencia de enfermedades mentales y cronicidad orgánica genera una comorbilidad con impacto en la salud, calidad de vida y eficiencia de los modelos de atención. Se necesita un enfoque ... -
Nutrient-mediated regulation of AMPAR receptors’ trafficking through the malonyl-CoA – CPT1C axis
(Date of defense: 2024-02-15)Actualment hi ha un creixent interès en l'impacte de les dietes en la cognició. És àmpliament conegut que el cervell requereix una gran quantitat d'energia per dur a terme les seves funcions vitals. La ... -
Desarrollo de nuevos métodos para el análisis del polifosfato en células humanas
(Date of defense: 2023-11-20)Nombre / Nom / Name Ana Apellidos / Cognoms / Surname Sarrias Giménez Dirección de correo electrónico / Adreça de correu electrònic / email address (opcional / optional) anasargim@gmail.com Departamento ... -
Characterization of new mutations in transferrin, DMT1 and SEC23B causing rare iron metabolism-related diseases; and the discovery of RACGAP1 as the gene responsible for autosomal recessive congenital dyserythropoietic anaemia type III
(Date of defense: 2023-11-25)Iron is a biometal involved in many physiological processes that are essential for life. Iron metabolism is a complex and tightly regulated process both at the systemic and cellular level. Proper iron ... -
Development of sol-gel silica-based 3D printable materials with tunable degradation, mechanical properties and drug release capacity for tissue engineering
(Date of defense: 2023-05-31)The bone is a very complex organ that participates in multiple critical functions for the human body. Bone can be affected by different health issues, such as physical trauma or tumor, and the body ... -
Development of novel bioinks formulations based on supramolecular self-assembled hydrogels for tissue regeneration.
(Date of defense: 2023-05-16)The field of tissue engineering relies on the use of biomaterials as scaffolds for tissue and organ regeneration. If properly designed, these scaffolds can mimic the in vivo microenvironment while also ... -
Increasing Forgiveness: design of two brief techniques based on the Social Learning Theory.
(Date of defense: 2017-11-15)Forgiveness is a human strength mainly helpful for the wellbeing of social relationships. Research has showed the potential benefits of forgiving for physical and mental health as well as for restoring ... -
Caracterización de complejos CDK-Ciclina atípicos humanos
(Date of defense: 2018-03-15)La desregulación en los mecanismos de control del ciclo celular es un evento indiscutiblemente asociado a la aparición de diversas patologías, entre las que destacan los procesos tumorales. Como principales ... -
CDK-mediated phosphorylation of Yku80 and its role in DNA repair
(Date of defense: 2021-03-11)DNA double-strand breaks (DSBs) are considered the most deleterious lesions of DNA and they are repaired by means of two main mechanisms: homologous recombination (HR) and non-homologous endjoining ... -
Estudi de la ciclina atípica CCNI com a potencial activador de CDK6 en línies de càncer de mama
(Date of defense: 2022-02-09)Fa quasi 40 anys del descobriment de les ciclines, les proteïnes oscil·lants tradicionalment dividies en dos grups, “cicle cel·lular” i “ciclines transcripcionals”, que duen a terme els seus rols juntament ... -
Caracterización molecular de nuevos substratos de la CDK Pho85
(Date of defense: 2013-07-29)La ciclina Cln3 es un activador crítico de START, cuya sobreexpresión provoca células de menor tamaño que progresan rápidamente por el ciclo celular, mientras que su deleción induce un mayor tamaño de ... -
Análisis de la respuesta neuromuscular y la proyección del ángulo de la rodilla en el plano frontal en sujetos físicamente activos: implicaciones para la lesión de ligamento cruzado anterior
(Date of defense: 2022-09-16)La lesión de ligamento cruzado anterior es una de las lesiones más devastadoras en el ámbito deportivo. El valgo dinámico de rodilla durante el gesto deportivo puede ser uno de los mecanismos más comunes ... -
El polifosfat és un element clau durant la replicació del DNA.
(Date of defense: 2015-11-06)Throughout its lifespan, eukaryotic cells steadily consume free cytoplasmic orthophosphate to produce phospholipids and mRNA. However, during DNA synthesis, in a matter of minutes, cells require large ... -
The pathway of forgiveness: unraveling the role of one’s decision to forgive
(Date of defense: 2019-04-01)Past research has suggested the potential benefits of forgiveness to overcome the negative consequences of experiencing interpersonal hurts. More specifically, forgiveness has been found to be very ... -
Extracellular UTP signalling in Schwann cell migration: A novel role of the P2Y2 receptor
(Date of defense: 2013-09-24)Peripheral neuropaties are one of the major complications of the Peripheral Nervous System. Depsite the big importance of those pathologies, less drugs are effective for their treatment, and most of the ... -
A bioengineering approach for corneal endothelial regeneration.
(Date of defense: 2019-07-31)Nowadays, there are approximately 10 million people worldwide with visual impairment due to corneal diseases. Currently, the main therapeutic solution is the transplant of a donor's cornea. The great ... -
Localización del foramen mandibular: estudio anatómico mediante tomografía computarizada (TC)
(Date of defense: 2012-08-01)Para la mayoría de tratamientos dentales, es efectiva la utilización de técnicas anestésicas de tipo infiltrativo, consiguiendo el bloqueo efectivo del estímulo doloroso en todos los dientes de la arcada ...