Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands

In this communication we report that anchoring αvβ3 or α5β1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.

Document Type

Article

Document version

Published version

Language

English

Subject (CDU)

616.3 - Pathology of the digestive system. Complaints of the alimentary canal

Keywords

Publisher

Royal Society of Chemistry

Collection

Is part of

Biomaterials Science

Recommended citation

Fraioli, R.; Neubauer, S.; Rechenmacher, F. [et al.]. Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands. Biomaterials Science, 2019, 4, p. 1281-1285. Disponible en: <https://pubs.rsc.org/en/content/articlelanding/2019/bm/c8bm01466c>. Fecha de acceso: 16 ene. 2025. DOI: 10.1039/C8BM01466C

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Odontologia [345]