dc.contributor.author | Villà, Salvador | |
dc.contributor.author | Weber, Damien C. | |
dc.contributor.author | Moretones, Cristina | |
dc.contributor.author | Mañes, Anabel | |
dc.contributor.author | Combescure, Christophe | |
dc.contributor.author | Jové, Josep | |
dc.contributor.author | Puyalto, Paloma | |
dc.contributor.author | Cuadras, Patricia | |
dc.contributor.author | Bruna, Jordi | |
dc.contributor.author | Verger, Eugènia | |
dc.contributor.author | Balañà, Carme | |
dc.contributor.author | Graus, Francesc | |
dc.date.accessioned | 2024-04-04T15:12:56Z | |
dc.date.available | 2024-04-04T15:12:56Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Villà, Salvador; Weber, Damien C.; Moretones, Cristina [et al.]. Validation of the new graded prognostic assessment scale for brain metastases: a multicenter prospective study. Radiation Oncology, 2011, 6, 23. Disponible en: <https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-6-23>. Fecha de acceso: 4 abr. 2024. DOI: 10.1186/1748-717X-6-23 | ca |
dc.identifier.issn | 1748-717X | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/4185 | |
dc.description.abstract | Background: Prognostic indexes are useful to guide tailored treatment strategies for cancer patients with brain metastasis (BM). We evaluated the new Graded Prognostic Assessment (GPA) scale in a prospective validation study to compare it with two published prognostic indexes. Methods: A total of 285 newly diagnosed BM (n = 85 with synchronous BM) patients, accrued prospectively between 2000 and 2009, were included in this analysis. Mean age was 62 ± 12.0 years. The median KPS and number of BM was 70 (range, 20-100) and 3 (range, 1-50), respectively. The majority of primary tumours were lung (53%), or breast (17%) cancers. Treatment was administered to 255 (89.5%) patients. Only a minority of patients could be classified prospectively in a favourable prognostic class: GPA 3.5-4: 3.9%; recursive partitioning analysis (RPA) 1, 8.4% and Basic Score for BM (BSBM) 3, 9.1%. Mean follow-up (FU) time was 5.2 ± 4.7 months. Results: During the period of FU, 225 (78.9%) patients died. The 6 months- and 1 year-OS was 36.9% and 17.6%, respectively. On multivariate analysis, performance status (P < 0.001), BSBM (P < 0.001), Center (P = 0.007), RPA (P = 0.02) and GPA (P = 0.03) were statistically significant for OS. The survival prediction performances' of all indexes were identical. Noteworthy, the significant OS difference observed within 3 months of diagnosis between the BSBM, RPA and GPA classes/groups was not observed after this cut-off time point. Harrell's concordance indexes C were 0.58, 0.61 and 0.58 for the GPA, BSBM and RPA, respectively. Conclusions: Our data suggest that the new GPA index is a valid prognostic index. In this prospective study, the prediction performance was as good as the BSBM or RPA systems. These published indexes may however have limited long term prognostication capability. | ca |
dc.format.extent | 8 | ca |
dc.language.iso | eng | ca |
dc.publisher | Springer Nature | ca |
dc.relation.ispartof | Radiation Oncology | ca |
dc.relation.ispartofseries | 6 | |
dc.rights | This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Metàstasi cerebral | ca |
dc.subject.other | Índex pronòstic | ca |
dc.subject.other | Grup d'Oncologia de Radioteràpia | ca |
dc.subject.other | Puntuació pronòstica | ca |
dc.subject.other | Anàlisi de particions recursives | ca |
dc.subject.other | Metástasis cerebral | ca |
dc.subject.other | Índice de pronóstico | ca |
dc.subject.other | Grupo de Oncología Radioterápica | ca |
dc.subject.other | Puntuación de pronóstico | ca |
dc.subject.other | Análisis de partición recursiva | ca |
dc.subject.other | Brain Metastasis | ca |
dc.subject.other | Prognostic Index | ca |
dc.subject.other | Radiation Therapy Oncology Group | ca |
dc.subject.other | Prognostic Score | ca |
dc.subject.other | Recursive Partitioning Analysis | ca |
dc.title | Validation of the new graded prognostic assessment scale for brain metastases: a multicenter prospective study | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.identifier.doi | https://dx.doi.org/10.1186/1748-717X-6-23 | ca |