Determination of soluble angiotensin-converting enzyme 2 in saliva samples and its association with nicotine
Autor/a
Bru, Samuel
González-Marrón, Adrián
Lidón-Moyano, Cristina
Carballar, Reyes
Martínez-Lainez, Joan Marc
Pérez-Martín, Hipólito
Fu, Marcela
Pérez-Ortuno, Raúl
Ballbè, Montse
Pascual, Jose A.
Fernandez, Esteve
Clotet, Josep
Martínez-Sanchez, Jose M.
Data de publicació
2023ISSN
0013-9351
Resum
Introduction: The Angiotensin-Converting Enzyme 2 (ACE2) is the main receptor of the SARS-CoV-2. There is contradictory evidence on how the exposure to nicotine may module the concentration of soluble ACE2 (sACE2). The aim of this study was to assess the association between nicotine and sACE2 concentrations in saliva samples. Methods: Pooled analysis performed with data retrieved from two studies (n = 634 and n = 302). Geometric mean (GM) concentrations of sACE2, both total and relative to the total amount of protein in the sample, were compared according to sociodemographic variables and variables associated to nicotine. Multivariable linear regression models were fitted to explore the associations of sACE2 with nicotine adjusting for sex, age and body mass index. Spearman’s rank-correlation coefficients were estimated between the concentrations of nicotine and cotinine, and pack-years, the concentration of relative sACE2 and the isoforms of sACE2. Results: We observed a significant increase of 0.108‰ and 0.087 ng/μl in the relative and absolute salivary sACE2 GM concentrations, respectively, between the lowest and highest nicotine levels. Similar results were observed for cotinine. These associations did not change in the multivariable linear models. There was a low correlation of nicotine and cotinine concentration with the concentration of relative salivary sACE2 (rs = 0.153 and rs = 0.132, respectively), pack-years (rs = 0.222 and rs = 0.235, respectively) and with the concentration of isoform 40 KDa (rs = 0.193 and rs = 0.140, respectively). Conclusion: Salivary nicotine concentration seems to be limitedly associated with the concentration of sACE2.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
61 - Medicina
Paraules clau
Enzima convertidor de l'angiotensina 2
Cotinina
COVID 19
Nicotina
Enzima convertidora de angiotensina 2
Cotinina
COVID-19
Nicotina
Angiotensin-converting enzyme 2
Cotinine
COVID-19
Nicotine
Pàgines
10
Publicat per
Elsevier
Col·lecció
216
Publicat a
Environmental Research
Citació
Bru, Samuel; González-Marrón, Adrián; Lidón-Moyano, Cristina [et al.]. Determination of soluble angiotensin-converting enzyme 2 in saliva samples and its association with nicotine. Environmental Research, 2023, 216, 114443. Disponible en: <https://www.sciencedirect.com/science/article/pii/S0013935122017704?via%3Dihub>. Fecha de acceso: 23 ene. 2024. DOI: 10.1016/j.envres.2022.114443
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Ciències de la Salut [725]
Drets
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