dc.contributor.author | Hernández, Gonzalo | |
dc.contributor.author | Ramírez, María José | |
dc.contributor.author | Minguillón, Jordi | |
dc.contributor.author | Quiles, Paco | |
dc.contributor.author | Ruiz de Garibay, Gorka | |
dc.contributor.author | Aza-Carmona, Miriam | |
dc.contributor.author | Bogliolo, Massimo | |
dc.contributor.author | Pujol, Roser | |
dc.contributor.author | Prados-Carvajal, Rosario | |
dc.contributor.author | Fernández, Juana | |
dc.contributor.author | García, Nadia | |
dc.contributor.author | López, Adrià | |
dc.contributor.author | Gutiérrez-Enríquez, Sara | |
dc.contributor.author | Diez, Orland | |
dc.contributor.author | Benítez, Javier | |
dc.contributor.author | Salinas, Mónica | |
dc.contributor.author | Teulé, Alex | |
dc.contributor.author | Brunet, Joan | |
dc.contributor.author | Radice, Paolo | |
dc.contributor.author | Peterlongo, Paolo | |
dc.contributor.author | Schindler, Detlev | |
dc.contributor.author | Huertas, Pablo | |
dc.contributor.author | Puente, Xose S. | |
dc.contributor.author | Lázaro, Conxi | |
dc.contributor.author | Pujana, Miquel Àngel | |
dc.contributor.author | Surrallés, Jordi | |
dc.date.accessioned | 2024-01-23T11:57:47Z | |
dc.date.available | 2024-01-23T11:57:47Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Hernández, Gonzalo; Ramírez, María José; Minguillón, Jordi [et al.]. Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1. Nature Communications, 2018, 9, 967. Disponible en: <https://www.nature.com/articles/s41467-018-03433-3>. Fecha de acceso: 23 ene. 2024. DOI: 10.1038/s41467-018-03433-3 | ca |
dc.identifier.issn | 2041-1723 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/3946 | |
dc.description.abstract | BRCA1 is a tumor suppressor that regulates DNA repair by homologous recombination. Germline mutations in BRCA1 are associated with increased risk of breast and ovarian cancer and BRCA1 deficient tumors are exquisitely sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. Therefore, uncovering additional components of this DNA repair pathway is of extreme importance for further understanding cancer development and therapeutic vulnerabilities. Here, we identify EDC4, a known component of processing-bodies and regulator of mRNA decapping, as a member of the BRCA1-BRIP1-TOPBP1 complex. EDC4 plays a key role in homologous recombination by stimulating end resection at double-strand breaks. EDC4 deficiency leads to genome instability and hypersensitivity to DNA interstrand cross-linking drugs and PARP inhibitors. Lack-of-function mutations in EDC4 were detected in BRCA1/2-mutation-negative breast cancer cases, suggesting a role in breast cancer susceptibility. Collectively, this study recognizes EDC4 with a dual role in decapping and DNA repair whose inactivation phenocopies BRCA1 deficiency. | ca |
dc.format.extent | 11 | ca |
dc.language.iso | eng | ca |
dc.publisher | Springer Nature | ca |
dc.relation.ispartof | Nature Communications | ca |
dc.relation.ispartofseries | 9 | |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Càncer | ca |
dc.subject.other | Inestabilitat genòmica | ca |
dc.subject.other | Metabolisme de l'ARN | ca |
dc.subject.other | Cancer | ca |
dc.subject.other | Genomic instability | ca |
dc.subject.other | RNA metabolism | ca |
dc.subject.other | Cáncer | ca |
dc.subject.other | Inestabilidad genómica | ca |
dc.subject.other | Metabolismo del ARN | ca |
dc.title | Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1 | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.identifier.doi | https://dx.doi.org/10.1038/s41467-018-03433-3 | ca |