Biomimetic mineralized hybrid scaffolds with antimicrobial peptides
Autor/a
Ye, Zhou
Zhu, Xiao
Mutreja, Isha
Kumar Boda, Sunil
Fischer, Nicholas G.
Zhang, Anqi
Lui, Christine
Qi, Yipin
Aparicio, Conrado
Fecha de publicación
2021-08ISSN
2452-199X
Resumen
Infection in hard tissue regeneration is a clinically-relevant challenge. Development of scaffolds with dual function for promoting bone/dental tissue growth and preventing bacterial infections is a critical need in the field. Here we fabricated hybrid scaffolds by intrafibrillar-mineralization of collagen using a biomimetic process and subsequently coating the scaffold with an antimicrobial designer peptide with cationic and amphipathic properties. The highly hydrophilic mineralized collagen scaffolds provided an ideal substrate to form a dense and stable coating of the antimicrobial peptides. The amount of hydroxyapatite in the mineralized fibers modulated the rheological behavior of the scaffolds with no influence on the amount of recruited peptides and the resulting increase in hydrophobicity. The developed scaffolds were potent by contact killing of Gram-negative Escherichia coli and Gram-positive Streptococcus gordonii as well as cytocompatible to human bone marrow-derived mesenchymal stromal cells. The process of scaffold fabrication is versatile and can be used to control mineral load and/or intrafibrillar-mineralized scaffolds made of other biopolymers.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
616.3 - Patología del aparato digestivo. Odontología
Palabras clave
Mineralització biomimètica
Antimicrobiana
Pèptids catiònics i amfipàtics
Citocompatibilitat del teixit dur
Mineralización biomimética
Antimicrobiano
Péptidos catiónicos y anfipáticos
Citocompatibilidad de tejido duro
Biomimetic mineralization
Antimicrobial
Cationic and amphipathic peptides
Hard tissue cytocompatibility
Páginas
11
Publicado por
Elsevier
Colección
6;8
Publicado en
Bioactive Materials
Citación
Ye, Zhou; Zhu, Xiao; Mutreja, Isha [et al.]. Biomimetic mineralized hybrid scaffolds with antimicrobial peptides. Bioactive Materials, 2021, 6(8), p. 2250-2260. Disponible en: <https://www.sciencedirect.com/science/article/pii/S2452199X21000037>. Fecha de acceso: 20 abr. 2023. DOI: 10.1016/j.bioactmat.2020.12.029
Enlace al documento relacionado
Este ítem aparece en la(s) siguiente(s) colección(ones)
- Odontologia [237]
Derechos
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Excepto si se señala otra cosa, la licencia del ítem se describe como https://creativecommons.org/licenses/by-nc-nd/4.0/