Heart rate variability, exercise capacity and levels of dailyphysical activity in children and adolescents withmild-to-moderate cystic ̄brosis
Author
De Freitas Coelho, Pitiguara
Ribeiro Batista Barbosa, Roberta
Dos Santos Lugao, Rodrigo
Mayrink Gonçalves Liberato, Fernanda
Reis Vidal, Pâmela
de Cássia Nunes Cruz Melotti, Roberta
Fagundes Donadio, Márcio Vinícius
Publication date
2022ISSN
1013-7025
Abstract
Background: Autonomic nervous system balance is altered in cystic fibrosis (CF), although its influence on physical fitness has been poorly explored. Objective: This study aimed to evaluate the association of heart rate variability (HRV) with exercise capacity and levels of daily physical activity in children and adolescents with mild-to-moderate CF. Methods: A cross-sectional study including individuals with CF aged 6–18 years, not under CFTR modulator therapy, was performed. Sociodemographic (age, sex) and clinical information (airway colonization, pancreatic insufficiency, and genotyping) were collected. In addition, exercise capacity (modified shuttle test — MST), lung function (spirometry), body composition (bioimpedance), levels of daily physical activity (5-day accelerometer), and HRV (both at rest and during the MST) were evaluated. Results: 30 individuals (20 females) aged 11.2±3.7 years, mean FEV162.8±27.6%, were included. A sympathovagal balance (LF/HF) increase (p<0.001) during the MST was shown, indicating a predominance of sympathetic modulation. The standard deviation of all RR intervals (SDNN) and the high frequency (HF) index during exercise correlated significantly with FEV1 (r=0.45, p=0.01 and r=0.46, p=0.01; respectively). MST distance also correlated positively and significantly with SDNN (r=0.43, p=0.01), square root of the mean of the sums of squares of frequencies between RR intervals greater than 50ms — RMSSD (r=0.53, p<0.01), low frequency — LF (r=0.48, p<0.01), HF (r=0.64, p<0.01), dispersion of points perpendicular to the short-term identity line — SD1 (r=0.40, p=0.02) and negatively with LF/HF (r=−0.57, p<0.01). Regarding daily physical activity, SDNN at rest (r=0.37, p=0.04) and exercise (r=0.41, p=0.02) showed positive correlations with time in moderate-to-vigorous activities. When normalizing the SDNN and classifying individuals as normal or altered, those presenting altered SDNN showed poorest FEV1 (p=0.001) and lower exercise capacity (p=0.027). Conclusion: HRV correlates with lung function, exercise capacity and levels of daily physical activity in children and adolescents with CF. The study highlights the influence of CF on autonomic function and suggests HRV measurement as an easy tool to be used in clinical settings as an alternative marker to monitor CF individuals.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Fibrosi quística
Variabilitat de la freqüència cardíaca
Capacitat d'exercici
Prova de llançadora modificada
Pediatria
Fibrosis quística
Variabilidad del ritmo cardíaco
Capacidad de ejercicio
Prueba de lanzadera modificada
Pediatría
Cystic fibrosis
Heart rate variability
Exercise capacity
Modified shuttle test
Pediatrics
Pages
10
Publisher
World Scientific Publishing
Collection
42; 1
Is part of
Hong Kong Physiotherapy Journal
Citation
Freitas Coelho, Pitiguara; Ribeiro Batista Barbosa, Roberta; Dos Santos Lugao, Rodrigo [et al.]. Heart rate variability, exercise capacity and levels of dailyphysical activity in children and adolescents withmild-to-moderate cystic brosis. Hong Kong Physiotherapy Journal, 2021, 42(1), 1-10. Disponible en: <https://www.worldscientific.com/doi/abs/10.1142/S1013702522500019>. Fecha de acceso: 8 mar. 2022. DOI: 10.1142/S1013702522500019
This item appears in the following Collection(s)
- Ciències de la Salut [740]
Rights
This is an Open Access article published by World Scientic Publishing Company. It is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 (CC BY-NC-ND) License which permits use, distribution and reproduction, provided that the original work is properly cited, the use isnon-commercial and no modi ̄cations or adaptations are made.
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