Multiple ion scaffold-based delivery platform for potential application in early stages of bone regeneration
Autor/a
Bosch Rué, Elia
Díez-Tercero, Leire
Rodríguez González, Raquel
A. Pérez, Román
Fecha de publicación
2021ISSN
1996-1944
Resumen
Bone has the intrinsic capacity to regenerate itself, as long as the damage is small, through the sequential stimulation of specific phases, such as angiogenesis followed by osteogenesis. However, when the damage is extensive it is unable to regenerate and bone tissue engineering is used as an alternative. In this study, we developed a platform to allow the triple ion delivery with sequential delivery capacity to potentially stimulate antibacterial, angiogenic and osteogenic processes. The scaffold-based platform consisted of alginate/hydroxyapatite (HA) microparticles embedded in alginate fibers. Firstly, microparticles were developed using different ratios of alginate:HA using the spraying method, resulting in a high reproducibility of the technique. Microparticle size between 100–300 µm and ratio 1:40 resulted in a more spherical morphology and were selected for their incorporation into alginate fiber. Different amounts of copper and cobalt were added with the microparticles and alginate fiber, respectively, were used as model ions which could eventually modulate and mimic antimicrobial and angiogenic processes. Moreover, calcium ion was also incorporated in both, in order to provide the system with potential osteogenic properties together with HA. The multiple delivery of copper, cobalt and calcium released were in the therapeutic range as measured by induced coupled plasma (ICP), providing a promising delivery strategy for tissue engineering.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
616.3 - Patología del aparato digestivo. Odontología
Palabras clave
Coure
Cobalt
Calci
Alliberament d'ions
Regeneració òssia
Angiogènesi
Osteogènesi
Propietats antimicrobianes
Cobre
Cobalto
Calcio
Liberación de iones
Regeneración ósea
Angiogénesis
Osteogénesis
Propiedades antimicrobianas
Copper
Cobalt
Calcium
Ion release
Bone regeneration
Angiogenesis
Osteogenesis
Antimicrobial properties
Páginas
16
Publicado por
MDPI
Colección
14;24
Publicado en
Materials
Citación
Bosch-Rué, Èlia; Díez-Tercero, Leire; Rodriguez-Gonzalez, Raquel [et al.]. Multiple ion scaffold-based delivery platform for potential application in early stages of bone regeneration. Materials, 2021, 14(24), 7676. Disponible en: <https://www.mdpi.com/1996-1944/14/24/7676>. Fecha de acceso: 14 ene. 2022. DOI: 10.3390/ma14247676
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