Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery: results of a pragmatic cohort study in Catalonia
Author
Badia, Josep M.
Flores-Yelamos, Miriam
Vázquez, Ana
Arroyo-García, Nares
Puig-Asensio, Mireia
Parés, David
Pera, Miguel
López-Contreras, Joaquín
Limón, Enric
Pujol, Miquel
Members Of The VINCat Colorectal Surveillance Team
Publication date
2021ISSN
2077-0383
Abstract
Background: The role of oral antibiotic prophylaxis (OAP) and mechanical bowel preparation (MBP) in the prevention of surgical site infection (SSI) after colorectal surgery is still controversial. The aim of this study was to analyze the effect of a bundle including both measures in a National Infection Surveillance Network in Catalonia. Methods: Pragmatic cohort study to assess the effect of OAP and MBP in reducing SSI rate in 65 hospitals, comparing baseline phase (BP: 2007–2015) with implementation phase (IP: 2016–2019). To compare the results, a logistic regression model was established. Results: Out of 34,421 colorectal operations, 5180 had SSIs (15.05%). Overall SSI rate decreased from 18.81% to 11.10% in BP and IP, respectively (OR 0.539, CI95 0.507–0.573, p < 0.0001). Information about bundle implementation was complete in 61.7% of cases. In a univariate analysis, OAP and MBP were independent factors in decreasing overall SSI, with OR 0.555, CI95 0.483–0.638, and OR 0.686, CI95 0.589–0.798, respectively; and similarly, organ/space SSI (O/S-SSI) (OR 0.592, CI95 0.494–0.710, and OR 0.771, CI95 0.630–0.944, respectively). However, only OAP retained its protective effect at both levels at multivariate analyses. Conclusions: oral antibiotic prophylaxis decreased the rates of SSI and O/S-SSI in a large series of elective colorectal surgery.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
617 - Surgery. Orthopaedics. Ophthalmology
Keywords
Cirurgia colorectal
Infecció del lloc quirúrgic
Infecció de la ferida quirúrgica
Profilaxi antibiòtica oral
Preparació mecànica de l'intestí
Mesures preventives
Cirugía colorrectal
Infección del sitio quirúrgico
Infección de herida quirúrgica
Profilaxis antibiótica oral
Preparación mecánica del intestino
Medidas preventivas
Colorectal surgery
Surgical site infection
Surgical wound infection
Oral antibiotic prophylaxis
Mechanical bowel preparation
Preventative measures
Pages
10
Publisher
MDPI
Collection
10; 23
Is part of
Journal of Clinical Medicine
Citation
Badia, Josep M.; Flores-Yelamos, Miriam; Vázquez, Ana [et al.]. Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery: results of a pragmatic cohort study in Catalonia. Journal of Clinical Medicine, 2021, 10(23), 5636. Disponible en: <https://www.mdpi.com/2077-0383/10/23/5636>. Fecha de acceso: 13 ene. 2022. DOI: 10.3390/jcm10235636
This item appears in the following Collection(s)
- Ciències de la Salut [740]
Rights
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/