Two opposing faces of retinoic acid: induction of stemness or induction of differentiation depending on cell-type
Visualitza/Obre
Autor/a
Mezquita, Belén
Mezquita, Cristóbal
Data de publicació
2019ISSN
2218-273X
Resum
Stem cells have the capacity of self-renewal and, through proliferation and differentiation, are responsible for the embryonic development, postnatal development, and the regeneration of tissues in the adult organism. Cancer stem cells, analogous to the physiological stem cells, have the capacity of self-renewal and may account for growth and recurrence of tumors. Development and regeneration of healthy tissues and tumors depend on the balance of different genomic and nongenomic signaling pathways that regulate stem cell quiescence, proliferation, and differentiation. During evolution, this balance became dependent on all-trans retinoic acid (RA), a molecule derived from the environmental factor vitamin A. Here we summarize some recent findings on the prominent role of RA on the proliferation of stem and progenitor cells, in addition to its well-known function as an inductor of cell differentiation. A better understanding of the regulatory mechanisms of stemness and cell differentiation by RA may improve the therapeutic options of this molecule in regenerative medicine and cancer.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
61 - Medicina
Paraules clau
Àcid retinoic
Diferenciació
Medicina regenerativa
Càncer
Ácido retinoico
Diferenciación
Medicina regenerativa
Cáncer
Retinoic acid
Differentiation
Regenerative medicine
Cancer
Pàgines
17
Publicat per
MDPI
Col·lecció
9;10
Publicat a
Biomolecules
Citació
Mezquita, Belén; Mezquita, Cristóbal. Two opposing faces of retinoic acid: induction of stemness or induction of differentiation depending on cell-type. Biomolecules, 2019, 9(10), 567. Disponible en: <https://www.mdpi.com/2218-273X/9/10/567>. Fecha de acceso: 10 dic. 2021. DOI: 10.3390/biom9100567
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Drets
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