Impedimetric antimicrobial peptide-based sensor for the early detection of periodontopathogenic bacteria

Novel researches are focused on the prevention and management of post-operative infections. To avoid this common complication of implant surgery, it is preferable to use new biomaterials with antibacterial properties. Therefore, the aim of this work is to develop a method of combining the antibacterial properties of antibiotic-loaded poly(3-hydroxybutyrate) (PHB) nano- and micro-spheres and poly(ethylene glycol) (PEG) as an antifouling agent, with titanium (Ti), as the base material for implants, in order to obtain surfaces with antibacterial activity. The Ti surfaces were linked to both PHB particles and PEG by a covalent bond. This attachment was carried out by firstly activating the surfaces with either Oxygen plasma or Sodium hydroxide. Further functionalization of the activated surfaces with different alkoxysilanes allows the reaction with PHB particles and PEG. The study confirms that the Ti surfaces achieved the antibacterial properties by combining the antibiotic-loaded PHB spheres, and PEG as an antifouling agent.

Document Type

Article

Document version

Accepted version

Language

English

Subject (CDU)

616.3 - Pathology of the digestive system. Complaints of the alimentary canal

Keywords

Angle de contacte

Microscopi electrònic d'exploració d'emissió de camp

Agent d'acoblament

Superfície de titani

Brou de soja triptona

Angulo de contacto

Microscopio electrónico de barrido de emisión de campo

Asesor de parejas

Superficie de titanio

Caldo de triptona soja

Contact angle

Field emission scan electron microscope

Coupling agent

Titanium surface

Tryptone soya broth

Publisher

Springer Nature

Collection

86;

Is part of

Journal of Materials Science: Materials in Medicine

Recommended citation

Rodriguez Contreras, Alejandra; Marqués Calvo, M. Soledad; Gil Mur, Francisco Javier [et al.]. Modification of titanium surfaces by adding antibiotic-loaded PHB spheres and PEG for biomedical applications. Journal of Materials Science: Materials in Medicine, 2016, 27, 124. Disponible en: <https://link.springer.com/article/10.1007%2Fs10856-016-5723-4>. Fecha de acceso: 12 nov. 2021. DOI: 10.1007/s10856-016-5723-4

Grant agreement number

info:eu-repo/grantAgreement/ES/MINECO/CTQ2014-54553- C3-1-R

info:eu-repo/grantAgreement/ES/MINECO/MAT2012-30706

info:eu-repo/grantAgreement/EC/FP7/321985

Note

The authors acknowledge financial support from the Spanish Government through projects CTQ2014-54553-C3-1-R and MAT2012–30706, cofunded by the European Union through European Regional Development Funds, the Government of Catalonia (SGR2009 1039), the Technical University of Catalonia (fellowship of M.H.) and the European Union (Project ENIAC-ED-52v161210, and FP7-PEOPLE-2012-CIG, REA Grant Agreement No. 321985). This work was partially supported by Government of Russian Federation, Grant 074-U01.

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Odontologia [345]