Impedimetric antimicrobial peptide-based sensor for the early detection of periodontopathogenic bacteria
Author
RODRIGUEZ-CONTRERAS, ALEJANDRA
Marqués-Calvo, María Soledad
Gil Mur, Francisco Javier
Manero, José María
Hoyos-Nogués, Mireia
BROSEL, SERGI
Abramova, Natalia
Muñoz, Francesc-Xavier
Bratov, Andrey
Mas-Moruno, Carlos
Publication date
2016ISSN
0956-5663
Abstract
Novel researches are focused on the prevention and management of post-operative infections. To avoid this common complication of implant surgery, it is preferable to use new biomaterials with antibacterial properties. Therefore, the aim of this work is to develop a method of combining the antibacterial properties of antibiotic-loaded poly(3-hydroxybutyrate) (PHB) nano- and micro-spheres and poly(ethylene glycol) (PEG) as an antifouling agent, with titanium (Ti), as the base material for implants, in order to obtain surfaces with antibacterial activity. The Ti surfaces were linked to both PHB particles and PEG by a covalent bond. This attachment was carried out by firstly activating the surfaces with either Oxygen plasma or Sodium hydroxide. Further functionalization of the activated surfaces with different alkoxysilanes allows the reaction with PHB particles and PEG. The study confirms that the Ti surfaces achieved the antibacterial properties by combining the antibiotic-loaded PHB spheres, and PEG as an antifouling agent.
Document Type
Article
Document version
Accepted version
Language
English
Subject (CDU)
616.3 - Pathology of the digestive system. Complaints of the alimentary canal
Keywords
Angle de contacte
Microscopi electrònic d'exploració d'emissió de camp
Agent d'acoblament
Superfície de titani
Brou de soja triptona
Angulo de contacto
Microscopio electrónico de barrido de emisión de campo
Asesor de parejas
Superficie de titanio
Caldo de triptona soja
Contact angle
Field emission scan electron microscope
Coupling agent
Titanium surface
Tryptone soya broth
Pages
9
Publisher
Springer Nature
Collection
86;
Is part of
Journal of Materials Science: Materials in Medicine
Citation
Rodriguez Contreras, Alejandra; Marqués Calvo, M. Soledad; Gil Mur, Francisco Javier [et al.]. Modification of titanium surfaces by adding antibiotic-loaded PHB spheres and PEG for biomedical applications. Journal of Materials Science: Materials in Medicine, 2016, 27, 124. Disponible en: <https://link.springer.com/article/10.1007%2Fs10856-016-5723-4>. Fecha de acceso: 12 nov. 2021. DOI: 10.1007/s10856-016-5723-4
Grant agreement number
info:eu-repo/grantAgreement/MINECO/CTQ2014-54553- C3-1-R
info:eu-repo/grantAgreement/MINECO/MAT2012-30706
info:eu-repo/grantAgreement/EC/FP7/321985
This item appears in the following Collection(s)
- Odontologia [226]
Rights
© 2021 Springer Nature Switzerland AG. Part of Springer Nature.