Physicochemical properties of lipoproteins assessed by nuclear magnetic resonance as a predictor of premature cardiovascular disease. PRESARV-SEA study
Autor/a
Fernández-Cidón, Bárbara
Candás-Estébanez, Beatriz
Gil-Serret, Miriam
Amigó, Núria
Corbella, Emili
Rodríguez-Sánchez, M. Ángeles
Padró-Miquel, Ariadna
Brotons, Carlos
Hernández-Mijares, Antonio
Calmarza, Pilar
Jarauta, Estibaliz
Brea, Angel J.
Mauri, Marta
Guijarro, Carlos
Vila, Àlex
Valdivielso, Pedro
Corbella Virós, Xavier
Pintó, Xavier
Fecha de publicación
2021ISSN
2077-0383
Resumen
Some lipoprotein disorders related to the residual risk of premature cardiovascular disease (PCVD) are not detected by the conventional lipid profile. In this case-control study, the predictive power of PCVD of serum sdLDL-C, measured using a lipoprotein precipitation method, and of the physicochemical properties of serum lipoproteins, analyzed by nuclear magnetic resonance (NMR) techniques, were evaluated. We studied a group of patients with a first PCVD event (n = 125) and a group of control subjects (n = 190). Conventional lipid profile, the size and number of Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL), High Density Lipoproteins (HDL) particles, and the number of particles of their subclasses (large, medium, and small) were measured. Compared to controls, PCVD patients had lower concentrations of all LDL particles, and smaller and larger diameter of LDL and HDL particles, respectively. PCVD patients also showed higher concentrations of small dense LDL-cholesterol (sdLDL), and triglycerides (Tg) in LDL and HDL particles (HDL-Tg), and higher concentrations of large VLDL particles. Multivariate logistic regression showed that sdLDL-C, HDL-Tg, and large concentrations of LDL particles were the most powerful predictors of PCVD. A strong relationship was observed between increased HDL-Tg concentrations and PCVD. This study demonstrates that beyond the conventional lipid profile, PCVD patients have other atherogenic lipoprotein alterations that are detected by magnetic resonance imaging (MRI) analysis.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
61 - Medicina
616.1 - Patología del sistema circulatorio, de los vasos sanguíneos. Transtornos cardiovasculares
Palabras clave
Cor -- Malalties
Circulació coronària
Lipoproteïnes
Lípids
Arteriosclerosi
Infart de miocardi
Miocardi -- Revascularització
Corazón -- Enfermedades
Circulación coronaria
Lipoproteínas
Lípidos
Arteriosclerosis
Infarto de miocardio
Revascularización miocárdica
Heart -- Diseases
Coronary circulation
Lipoproteins
Lipids
Arteriosclerosis
Myocardial infarction
Myocardium -- Revascularization
Páginas
10
Publicado por
MDPI
Colección
10;7
Publicado en
Journal of Clinical Medicine
Citación
Fernández-Cidón, Bárbara; Candás-Estébanez, Beatriz; Gil-Serret, Miriam [et al.]. Physicochemical properties of lipoproteins assessed by nuclear magnetic resonance as a predictor of premature cardiovascular disease. PRESARV-SEA study. Journal of Clinical Medicine, 2021, 10(7), 1379. Disponible en: <https://www.mdpi.com/2077-0383/10/7/1379>. Fecha de acceso: 18 may. 2021. DOI: 10.3390/jcm10071379
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Derechos
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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