Implication between genetic variants from APOA5 and ZPR1 and NAFLD severity in patients with hypertriglyceridemia
Author
Esteve-Luque, Virginia
Padró-Miquel, Ariadna
Fanlo-Maresma, Marta
Corbella, Emili
Corbella Virós, Xavier
Pintó, Xavier
Candás-Estébanez, Beatriz
Publication date
2021ISSN
2072-6643
Abstract
Background: Lipid metabolism disorders, especially hypertriglyceridemia (HTG), are risk factors for non-alcoholic fatty liver disease (NAFLD). However, the association between genetic factors related to HTG and the risk of NAFLD has been scarcely studied. Methods: A total of 185 subjects with moderate HTG were prospectively included. We investigated the association between genetic factors’ (five allelic variants with polygenic hypertriglyceridemia) clinical and biochemical biomarkers with NAFLD severity. The five allelic variants’ related clinical and biochemical data of HTG were studied in all the subjects. NAFLD was assessed by abdominal ultrasound and patients were divided into two groups, one with no or mild NAFLD and another with moderate/severe NAFLD. Results: Patients with moderate/severe NAFLD had higher weight and waist values and a higher prevalence of insulin resistance than patients with no or mild NAFLD. Moderate/severe NAFLD was independently associated with APOA5 rs3134406 and ZPR1 rs964184 variants, and also showed a significant inverse relationship with lipoprotein(a) [Lp(a)] concentrations. Conclusions: APOA5 rs3135506 and ZPR1 rs964184 variants and lipoprotein(a) are associated with moderate/severe NAFLD. This association was independent of body weight, insulin resistance, and other factors related to NAFLD.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Genètica
Diferenciació cel·lular
Hipertriacilgliceridèmia
Metabolisme
Fetge
Genética
Diferenciación celular
Metabolismo
Hígado
Genetics
Cell differentiation
Hypertriglyceridemia
Metabolism
Liver
Pages
11
Publisher
MDPI
Collection
13; 2
Is part of
Nutrients
Citation
Esteve-Luque, Virginia; Padró-Miquel, Ariadna; Fanlo-Maresma, Marta [et al.]. Implication between genetic variants from APOA5 and ZPR1 and NAFLD severity in patients with hypertriglyceridemia. Nutrients, 2021, 13(2), 552. Disponible en: <https://www.mdpi.com/2072-6643/13/2/552>. Fecha de acceso: 24 feb. 2021. DOI: 10.3390/nu13020552
This item appears in the following Collection(s)
- Ciències de la Salut [740]
Rights
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/