Pneumonia in children admitted to the national referral hospital in Bhutan: a prospective cohort study
Autor/a
Jullien, Sophie
Pradhan, Dinesh
Tshering, Tashi
Sharma, Ragunath
Dema, Kumbu
Garcia-Garcia, Selene
Ribó, Jose Luis
Muñoz-Almagro, Carmen
Bassat, Quique
Fecha de publicación
2020-06ISSN
1201-9712
Resumen
Objectives: The study aim was to describe the etiological profile and clinical characteristics of pneumonia among children hospitalized in Thimphu, Bhutan. Methods: This prospective study enrolled children aged 2–59 months admitted to the Jigme Dorji Wangchuck National Referral Hospital with World Health Organization (WHO)-defined clinical pneumonia. Demographic and clinico-radiological data were collected through questionnaires, physical examination, and chest radiography. Blood samples and nasopharyngeal washing were collected for microbiological analysis including culture and molecular methods. Results: From July 2017 to June 2018, 189 children were enrolled, of which 53.4% were infants. Pneumonia-related admissions were less frequent over the winter. Chest radiographies were obtained in 149 children; endpoints included pneumonia in 39 cases (26.2%), other infiltrates in 31 (20.8%), and were normal in 79 children (53.0%). Non-contaminated bacterial growth was detected in 8/152 (5.3%) blood cultures, with only two cases of Streptococcus pneumoniae. Viral detection in upper respiratory secretions was common, with at least one virus detected in 103/115 (89.6%). The three most-commonly isolated viruses were respiratory syncytial virus (52/115; 45.2%), rhinovirus (42/115; 36.5%), and human parainfluenza virus (19/115; 16.5%). A third of patients with viral infections showed mixed infections. Case fatality rate was 3.2% (6/189). Conclusion: Respiratory viral infections predominated among this cohort of WHO-defined clinical pneumonia cases, whereas bacterial aetiologies were uncommon, highlighting the epidemiologic transition that Bhutan seems to have reached.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
61 - Medicina
Palabras clave
Pneumònia
Infecció
Virus
Epidemiologia
Infants -- Salud i higiene
Neumonía
Infección
Virus
Epidemiología
Niños -- Salud e higiene
Pneumonia
Infection
Virus
Epidemiology
Children -- Health and hygiene
Páginas
10
Publicado por
Elsevier
Colección
95;
Publicado en
International Journal of Infectious Diseases
Citación
Jullien, Sophie; Pradhan, Dinesh; Tshering, Tashi [et al.]. Pneumonia in children admitted to the national referral hospital in Bhutan: a prospective cohort study. International Journal of Infectious Diseases, 2020, 95, p. 74-83. Disponible en: <https://www.sciencedirect.com/science/article/pii/S1201971220302332?via%3Dihub>. Fecha de acceso: 16 feb. 2021. DOI: 10.1016/j.ijid.2020.04.017
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Derechos
© 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). International Journal of Infectious Diseases 95 (2020 ) 74–83 Contents lists available at Science Direct International Journal of Infectious Diseases journal homepage: www.elsevier.com/locate/ijid
Excepto si se señala otra cosa, la licencia del ítem se describe como http://creativecommons.org/licenses/by-nc-nd/4.0/