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dc.contributor.authorPalomo-Guerrero, Marta
dc.contributor.authorFadó Andrés, Rut
dc.contributor.authorCasas, Maria
dc.contributor.authorPérez-Montero, Marta
dc.contributor.authorBaena, Miguel
dc.contributor.authorHelmer, Patrick O.
dc.contributor.authorDomínguez, José Luis
dc.contributor.authorRoig, Aina
dc.contributor.authorSerra, Dolors
dc.contributor.authorHayen, Heiko
dc.contributor.authorStenmark, Harald
dc.contributor.authorRaiborg, Camilla
dc.contributor.authorCasals, Núria
dc.date.accessioned2020-05-27T15:45:22Z
dc.date.available2020-05-27T15:45:22Z
dc.date.issued2019
dc.identifier.citationPalomo-Guerrero, Marta; Fadó Andrés, Rut; Casas, Maria [et al.]. Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth. eLife, 2019, 8, e51063. Disponible en: <https://elifesciences.org/articles/51063>. Fecha de acceso: 27 may. 2020. DOI: 10.7554/eLife.51063.ca
dc.identifier.issn2050-084Xca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/1551
dc.description.abstractAnterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty acids, and its intracellular levels highly fluctuate depending on glucose availability or the energy sensor AMP-activated protein kinase (AMPK). We demonstrate in HeLa cells that carnitine palmitoyltransferase 1C (CPT1C) senses malonyl-CoA and enhances LE/Lys anterograde transport by interacting with the endoplasmic reticulum protein protrudin and facilitating the transfer of Kinesin-1 from protrudin to LE/Lys. In cultured mouse cortical neurons, glucose deprivation, pharmacological activation of AMPK or inhibition of malonyl-CoA synthesis decreases LE/Lys abundance at the axon terminal, and shortens axon length in a CPT1C-dependent manner. These results identify CPT1C as a new regulator of anterograde LE/Lys transport in response to malonyl-CoA changes, and give insight into how axon growth is controlled by nutrients.ca
dc.format.extent26ca
dc.language.isoengca
dc.publishereLife Sciences Publicationsca
dc.relation.ispartofeLifeca
dc.relation.ispartofseries8;
dc.rights© Palomo-Guerrero et. al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.ca
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.otherLisosomesca
dc.subject.otherÀcids grassos
dc.subject.otherGlucosa
dc.subject.otherNeurones
dc.subject.otherAxons
dc.subject.otherCitologia
dc.subject.otherNeurociències
dc.subject.otherRatolins
dc.subject.otherLisosomas
dc.subject.otherÁcidos grasos
dc.subject.otherGlucosa
dc.subject.otherNeuronas
dc.subject.otherAxiomas
dc.subject.otherCitología
dc.subject.otherNeurociencias
dc.subject.otherRatones
dc.subject.otherLysosomes
dc.subject.otherFatty acids
dc.subject.otherGlucose
dc.subject.otherNeurons
dc.subject.otherAxons
dc.subject.otherCytology
dc.subject.otherNeurosciences
dc.subject.otherMice
dc.titleSensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growthca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca
dc.embargo.termscapca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2PE/SAF2017-83813-C3-1-Rca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/SAF2014-52223-C2-2-Rca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2PE/SAF2017-82813-C3-3Rca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/SAF2014-52223-C2-1-Rca
dc.subject.udc61ca
dc.identifier.doihttp://dx.doi.org/10.7554/eLife.51063ca


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© Palomo-Guerrero et. al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/