Mechanical and physicochemical characterization along with biological interactions of a new Ti25Nb21Hf alloy for bone tissue engineering
Author
Herranz-Diez, Carolina
Gil Mur, Francisco Javier
Guillem Martí, Jordi
Manero Planella, José María
Publication date
2015-03-23ISSN
0885-3282
Abstract
Nowadays, one of the main challenges in metal implants for bone substitution is the achievement of an elastic modulus close to that of human cortical bone as well as to provide an adequate interaction with the surrounding tissue avoiding in vivo foreign body reaction. From this perspective, a new Ti-based alloy has been developed with Nb and Hf as alloying elements which are known as non-toxic and with good corrosion properties. The microstructure, mechanical behaviour and the physicochemical properties of this novel titanium alloy have been studied. Relationship of surface chemistry and surface electric charge with protein adsorption and cell adhesion has been evaluated due to its role for understanding the mechanism of biological interactions with tissues. The Ti25Nb21Hf alloy presented a lower elastic modulus than commercial alloys with a superior ultimate strength and yield strength than CP-Ti and very close to Ti6Al4V. It also exhibited good corrosion resistance. Furthermore, the results revealed that it had no cytotoxic effect on rat mesenchymal stem cells and allowed protein adsorption and cell adhesion. The experimental results make this alloy a promising material for bone substitution or for biomedical devices.
Document Type
Article
Document version
Accepted version
Language
English
Subject (CDU)
57 - Biological sciences in general
Keywords
Cèl·lules
Titani
Proteïnes
Electroquímica
Células
Titanio
Proteínas
Electroquímica
Cells
Titanium
Proteins
Electrochemistry
Pages
31
Publisher
SAGE Publications
Collection
30;2
Is part of
Journal of Biomaterials Applications
Citation
Herranz-Diez, C.; Gil Mur, F.J.; Guillem-Marti, J. [et al.]. Mechanical and physicochemical characterization along with biological interactions of a new Ti25Nb21Hf alloy for bone tissue engineering. Journal of Biomaterials Applications, 2015, 30(2), p. 171-181. Disponible en: <https://journals.sagepub.com/doi/abs/10.1177/0885328215577524?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=jbaa>. Fecha de acceso: 9 may 2020. DOI: 10.1177/0885328215577524
Grant agreement number
info:eu-repo/grantAgreement/MINECO/6PN/MAT2012-30706
This item appears in the following Collection(s)
- Ciències de la Salut [712]
Rights
© 2020 by SAGE Publications