Pomace olive oil concentrated in triterpenic acids restores vascular function, glucose tolerance and obesity progression in mice
Author
Claro-Cala, Carmen Maria
Quintela, Jose Carlos
Pérez-Montero, Marta
Miñano, Javier
Alvarez de Sotomayor, María
Dolores Herrera, María
Rodríguez-Rodríguez, Rosalía
Publication date
2020-01ISSN
2072-6643
Abstract
Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on metabolic complications of obesity, this study investigates for the first time the dietary intervention with a pomace olive oil with high concentrations of the triterpenic acids (POCTA), oleanolic and maslinic acid, during diet-induced obesity in mice. The results demonstrate that obese mice, when switched to a POCTA-diet for 10 weeks, show a substantial reduction of body weight, insulin resistance, adipose tissue inflammation, and particularly, improvement of vascular function despite high caloric intake. This study reveals the potential of a functional food based on pomace olive oil and its triterpenic fraction against obesity progression. Our data also contribute to understanding the health-promoting effects attributable to the Mediterranean diet.
Document Type
Article
Document version
Accepted version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Obesitat
Metabolisme
Glucosa
Dieta
Insulinoresistència
Obesity
Metabolism
Glucose
Diet
Insulin resistance
Obesidad
Metabolismo
Glucosa
Dieta
Insulinorresistencia
Pages
14
Publisher
MDPI
Collection
12;2
Is part of
Nutrients
Citation
Claro-Cala, Carmen Maria; Quintela, Jose Carlos; Pérez-Montero, Marta [et al.]. Pomace olive oil concentrated in triterpenic acids restores vascular function, glucose tolerance and obesity progression in mice. Nutrients, 2020, vol. 12, núm. 2, e323. Disponible en: <https://www.mdpi.com/2072-6643/12/2/323>. Fecha de acceso: 1 mar. 2020. DOI: 10.3390/nu12020323
Grant agreement number
info:eu-repo/grantAgreement/ES/2PE/SAF2017-82813-C3-3-R
info:eu-repo/grantAgreement/ES/2PE/PCI2018-092997/AEI
This item appears in the following Collection(s)
- Ciències de la Salut [725]
Rights
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/