Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders
Autor/a
Mingorance, Carmen
Rodríguez-Rodríguez, Rosalía
Justo, María Luisa
Álvarez de Sotomayor, María
Dolores Herrera, María
Fecha de publicación
2011-03-28ISSN
1178-2048
Resumen
Acetyl-L-carnitine (ALC) and propionyl-L-carnitine (PLC) are two naturally occurring carnitine derivates formed by carnitine acetyltransferase. The beneficial cardiovascular effects of ALC and PLC have been extensively evaluated in animals and humans during the last 20 years. For instance, many clinical trials have suggested ALC and PLC as potential strategies in the management of peripheral arterial disease, heart and cerebral ischemia, and congestive heart failure. As a result, several experts have already aimed to revise the clinical evidence supporting the therapeutic use of ALC and PLC. On the basis of their conclusions, our aim was a critical review of the effectiveness of ALC and PLC in the treatment of cardiovascular diseases. Type 2 diabetes mellitus is an independent risk factor for the development of cardiovascular disease. Therefore we also describe recent studies that have addressed the emerging use of ALC and PLC amelioration of the insulin resistant state and its related morbidities.
Tipo de documento
Artículo
Versión del documento
Versión aceptada
Lengua
English
Materias (CDU)
61 - Medicina
Palabras clave
Sistema cardiovascular--Malalties
Insulinoresistència
Aparato circulatorio--Enfermedades
Insulinorresistencia
Cardiovascular system--Diseases
Insulin resistance
Páginas
8
Publicado por
Dove Press
Colección
2011; 7
Publicado en
Vascular Health and Risk Management
Citación
Mingorance, Carmen; Rodríguez Rodríguez, Rosalía; Justo, María Luisa [et al.]. Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders. Vascular Health and Risk Management, 2011, vol. 2011, núm 7, p. 169-176. Disponible en: <https://www.dovepress.com/critical-update-for-the-clinical-use-of-l-carnitine-analogs-in-cardiom-peer-reviewed-article-VHRM>. Fecha de acceso: 3 ene. 2020. DOI: 10.2147/VHRM.S14356.
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