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Proteasomal-mediated degradation of AKAP150 accompanies AMPAR endocytosis during cLTD
(Society for Neuroscience, 2020-03-23)
The number and function of synaptic AMPA receptors (AMPARs) tightly regulates excitatory synaptic transmission. Current evidence suggests that AMPARs are inserted into the postsynaptic membrane during ...
The return of malonyl-CoA to the brain: cognition and other stories
(Elsevier, 2021-01)
Nutrients, hormones and the energy sensor AMP-activated protein kinase (AMPK) tightly regulate the intracel-lular levels of the metabolic intermediary malonyl-CoA, which is a precursor of fatty ...
Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking
(Rockefeller University Press, 2020)
Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ...
Feeding the brain: effect of nutrients on cognition, synaptic function, and AMPA receptors
(MDPI, 2022)
In recent decades, traditional eating habits have been replaced by a more globalized diet, rich in saturated fatty acids and simple sugars. Extensive evidence shows that these dietary factors contribute ...
To be or not to be a fat burner, that is the question for cpt1c in cancer cells
(Springer Nature, 2023)
There is an urgent need to identify reliable genetic biomarkers for accurate diagnosis, prognosis, and treatment of different tumor types. Described as a prognostic marker for many tumors is the neuronal ...