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Knowledge management for systems biology a general and visually driven framework applied to translational medicine
(BMC Systems Biology, 2011)
Background: To enhance our understanding of complex biological systems like diseases we need to put all of the available data into context and use this to detect relations, pattern and rules which allow ...
Traumatismes desapercebuts en un adolescent amb intoxicació etílica aguda: a propòsit d'un cas
(Societat Catalana de Pediatria, 2011)
Introducció. Són ben coneguts els efectes deleteris directament associats a la intoxicació etílica aguda, així com la seva associació amb factors comòrbids, com el consum simultani d'altres substàncies ...
A nucleotide-based drug protects against glutamate- and MPP+ -induced neurotoxicity
(Scientific Research, 2011)
Nucleo CMP Forte® is a nucleotide-based drug consisting of cytidinemonophosphate, uridinemonophosphate, uridin-ediphosphate and uridinetriphosphate. It has been prescribed for peripheral nervous system ...
Missense SLC25A38 variations play an important role in autosomal recessive inherited sideroblastic anemia
(Ferrata Storti Foundation, 2011)
Congenital sideroblastic anemias are rare disorders with several genetic causes; they are characterized by erythroblast mitochondrial iron overload, differ greatly in severity and some occur within a ...
Exploring the link between MORF4L1 and risk of breast cancer
(Springer Nature, 2011)
Introduction: Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. To gain deeper insight into this pathway ...
Validation of the new graded prognostic assessment scale for brain metastases: a multicenter prospective study
(Springer Nature, 2011)
Background: Prognostic indexes are useful to guide tailored treatment strategies for cancer patients with brain metastasis (BM). We evaluated the new Graded Prognostic Assessment (GPA) scale in a ...
Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins
(ASH Publications, 2011)
Iron regulatory proteins (IRPs) 1 and 2 are RNA-binding proteins that control cellular iron metabolism by binding to conserved RNA motifs called iron-responsive elements (IREs). The currently known ...
Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders
(Dove Press, 2011-03-28)
Acetyl-L-carnitine (ALC) and propionyl-L-carnitine (PLC) are two naturally occurring carnitine derivates formed by carnitine acetyltransferase. The beneficial cardiovascular effects of ALC and PLC have ...
Soluble oligomers of amyloid-β peptide disrupt Membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction
(Elsevier, 2011-08-05)
β-Amyloid (Aβ), a peptide generated from the amyloid precursor protein, is widely believed to underlie the pathophysiology of Alzheimer disease (AD). Emerging evidences suggest that soluble Aβ oligomers ...
Impacto de la violencia colectiva en la salud. Resultados del estudio ISAVIC en el País Vasco
(Elsevier, 2011)
Objetivo: A pesar de la ubicuidad de la violencia y de su posible importancia para la salud de las personas y las colectividades, su papel y mecanismos de acción en este sentido no están apenas analizados. ...