Now showing items 1-4 of 4
Knowledge management for systems biology a general and visually driven framework applied to translational medicine
(BMC Systems Biology, 2011)
Background: To enhance our understanding of complex biological systems like diseases we need to put all of the available data into context and use this to detect relations, pattern and rules which allow ...
A nucleotide-based drug protects against glutamate- and MPP+ -induced neurotoxicity
(Neuroscience & Medicine, 2011)
Nucleo CMP Forte® is a nucleotide-based drug consisting of cytidinemonophosphate, uridinemonophosphate, uridin-ediphosphate and uridinetriphosphate. It has been prescribed for peripheral nervous system ...
Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12
(Cell Death and Disease, 2011-04-28)
Disturbance of calcium homeostasis and accumulation of misfolded proteins in the endoplasmic reticulum (ER) are considered contributory components of cell death after ischemia. However, the signal-transducing ...
Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders
(Vascular Health and Risk Management, 2011-03-28)
Acetyl-L-carnitine (ALC) and propionyl-L-carnitine (PLC) are two naturally occurring carnitine derivates formed by carnitine acetyltransferase. The beneficial cardiovascular effects of ALC and PLC have ...