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Ghrelin causes a decline in GABA release by reducing fatty acid oxidation in cortex
(Springer Nature, 2018)
Lipid metabolism, specifically fatty acid oxidation (FAO) mediated by carnitine palmitoyltransferase (CPT) 1A, has been described to be an important actor of ghrelin action in hypothalamus. However, it ...
CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity
(Journal of Biological Chemistry, 2008)
CPT1c is a carnitine palmitoyltransferase 1 (CPT1) isoform that is expressed only in the brain. The enzyme has recently been localized in neuron mitochondria. Although it has high sequence identity with ...
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty ...