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The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation
(Nature Communications, 2012-08-21)
Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size ...
Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast
(PLoS Biology, 2018-08-06)
Cell size scales with ploidy in a great range of eukaryotes, but the underlying mechanisms
remain unknown. Using various orthogonal single-cell approaches, we show that cell size
increases linearly ...
Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1
(eLife, 2019-09-13)
Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct
cause-effect relationships are not well understood. We show that most yeast cells arrest in G1
before death with low ...
Study on the use of 3‐aminopropyltriethoxysilane and 3‐chloropropyltriethoxysilane to surface biochemical modification of a novel low elastic modulus Ti–Nb–Hf alloy
(Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2014-06-09)
A biocompatible new titanium alloy Ti–16Hf–25Nb with low elastic modulus (45 GPa) and the use of short bioadhesive peptides derived from the extracellular matrix have been studied. In terms of cell ...
Comprehensive and quantitative analysis of G1 cyclins. A tool for studying the cell cycle
(PLoS One, 2019-06-25)
In eukaryotes, the cell cycle is driven by the actions of several cyclin dependent kinases (CDKs) and an array of regulatory proteins called cyclins, due to the cyclical expression patterns of the latter. ...
Red blood cell distribution width as a prognostic factor of mortality in elderly patients firstly hospitalized due to heart failure
(Kardiologia Polska, 2019-04-29)
Background: Red blood cell distribution width (RDW) is a risk factor related to adverse outcome in patients with heart failure (HF). Less is known about its role in patients in their first hospitalization ...
Mechanical and physicochemical characterization along with biological interactions of a new Ti25Nb21Hf alloy for bone tissue engineering
(Journal of Biomaterials Applications, 2015-03-23)
Nowadays, one of the main challenges in metal implants for bone substitution is the achievement of an elastic modulus close to that of human cortical bone as well as to provide an adequate interaction ...
Nucleosome architecture throughout the cell cycle
(Scientific Reports, 2016-01-28)
Nucleosomes provide additional regulatory mechanisms to transcription and DNA replication
by mediating the access of proteins to DNA. During the cell cycle chromatin undergoes several
conformational ...
Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress
(Life Science Alliance, 2019-04-15)
The precise coordination of growth and proliferation has a
universal prevalence in cell homeostasis. As a prominent
property, cell size is modulated by the coordination between
these processes in ...
Growth rate as a direct regulator of the start network to set cell size
(Frontiers in Cell and Developmental Biology, 2017-05-26)
Cells are able to adjust their growth and size to external inputs to comply with specific
fates and developmental programs. Molecular pathways controlling growth also have
an enormous impact in cell ...