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Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

Palomo-Guerrero, Marta; Fadó Andrés, Rut; Casas, Maria; Pérez-Montero, Marta; Baena, Miguel; Helmer, Patrick O.; Domínguez, José Luis; Roig, Aina; Serra, Dolors; Hayen, Heiko; Stenmark, Harald; Raiborg, Camilla; Casals, Núria (eLife, 2019)

Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty ...

Increased infammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice

Alcalá, Martín; Calderon-Dominguez, María; Bustos, Eduviges; Ramos, Pilar; Casals i Farré, Núria; Serra, Dolors; Viana, Marta; Herrero, Laura (Scientific Reports, 2017-11-22)

Obesity is associated with severe metabolic diseases such as type 2 diabetes, insulin resistance, cardiovascular disease and some forms of cancer. The pathophysiology of obesity-induced metabolic diseases ...

Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice

Miralpeix, Cristina; Fosch, Anna; Casas, Josefina; Baena, Miguel; Herrero, Laura; Serra, Dolors; Rodríguez-Rodríguez, Rosalía; Casals, Núria (Journal of Lipid Research, 2019-07)

The endocannabinoid (eCB) system regulates energy homeostasis and is linked to obesity development. However, the exact dynamic and regulation of eCBs in the hypothalamus during obesity progression remain ...

Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance

Contreras, Cristina; González-García, Ismael; Martínez-Sánchez, Noelia; Seoane-Collazo, Patricia; Jacas, Jordi; Morgan, Donald A.; Serra, Dolors; Gallego, Rosalía; Gonzalez, Francisco; Casals i Farré, Núria; Nogueiras, Rubén; Rahmouni, Kamal; Diéguez, Carlos; López, Miguel (Cell Reports, 2014-10)

Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity. Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress, leading to sympathetic inhibition, ...

Structural (betaalpha) 8 TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase

Casals Farré, Núria; Gómez-Puertas, Paulino; Pié, Juan; Mir, Cecilia; Roca, Ramón; Puisac, Beatriz; Aledo, Rosa; Clotet, Josep; Menao, Sebastián; Serra, Dolors; Asins, Guillermina; Till, Jacqueline; Elias-Jones, Alun C.; Cresto, Juan C.; Chamoles, Nestor A.; Abdenur, Jose E.; Mayatepek, Ertan; Besley, Guy; Valencia, Alfonso; Hegardt, Fausto G. (Journal of Biological Chemistry, 2003)

This study describes three novel homozygous missense mutations (S75R, S201Y, and D204N) in the 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) lyase gene, which caused 3-hydroxy-3-methylglutaric aciduria in ...

CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy

Roa-Mansergas, Xavier; Fadó Andrés, Rut; Atari Abouassi, Maher; Mir, Joan F.; Muley, Helena; Serra, Dolors; Casals i Farré, Núria (Scientific Reports, 2018-05-03)

Human mesenchymal stem cells (hMSCs) are widely used in regenerative medicine. In some applications, they must survive under low nutrient conditions engendered by avascularity. Strategies to improve ...

CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity

Sierra, Adriana Y.; Gratacós, Esther; Carrasco, Patricia; Clotet, Josep; Ureña, Jesús; Serra, Dolors; Asins, Guillermina; Hegardt, Fausto G.; Casals Farré, Núria (Journal of Biological Chemistry, 2008)

CPT1c is a carnitine palmitoyltransferase 1 (CPT1) isoform that is expressed only in the brain. The enzyme has recently been localized in neuron mitochondria. Although it has high sequence identity with ...

Ghrelin causes a decline in GABA release by reducing fatty acid oxidation in cortex

Mir, Joan Francesc; Zagmutt, Sebastián; Lichtenstein, Mathieu P.; García-Villoria, Judit; Weber, Minéia; Gracia, Ana; Fabriàs, Gemma; Casas, Josefina; López, Miguel; Casals Farré, Núria; Ribes, Antònia; Suñol, Cristina; Herrero, Laura; Serra, Dolors (Springer Nature, 2018)

Lipid metabolism, specifically fatty acid oxidation (FAO) mediated by carnitine palmitoyltransferase (CPT) 1A, has been described to be an important actor of ghrelin action in hypothalamus. However, it ...

CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity

Rodríguez-Rodríguez, Rosalía; Miralpeix, Cristina; Fosch, Anna; Pozo, Macarena; Calderón-Domínguez, María; Perpinyà, Xavier; Vellvehí, Miquel; López, Miguel; Herrero, Laura; Serra, Dolors; Casals i Farré, Núria (Molecular Metabolism, 2019-01)

Objective: Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis. Our aim was to investigate whether CPT1C in the ventromedial nucleus of the hypothalamus ...

Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD

Weber, Minéia; Mera, Paula; Casas, Josefina; Salvador, Javier; Rodríguez, Amaia; Alonso, Sergio; Sebastián, David; Soler-Vázquez, M. Carmen; Montironi, Carla; Recalde, Sandra; Fucho, Raquel; Calderón-Domínguez, María; Mir, Joan Francesc; Bartrons, Ramon; Escola-Gil, Joan Carles; Sánchez-Infantes, David; Zorzano, Antonio; Llorente-Cortes, Vicenta; Casals Farré, Núria; Valentí, Víctor; Frühbeck, Gema; Herrero, Laura; Serra, Dolors (Federation of American Societies for Experimental Biology, 2020)

The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased drastically due to the global obesity pandemic but at present there are no approved therapies. Here, we aimed to revert high‐fat ...