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Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast
(Public Library of Science, 2018-08-06)
Cell size scales with ploidy in a great range of eukaryotes, but the underlying mechanisms
remain unknown. Using various orthogonal single-cell approaches, we show that cell size
increases linearly ...
A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer
(Scientific Reports, 2017-08-31)
As lung cancer has increased to the most common cause of cancer death worldwide, prognostic
biomarkers and efective targeted treatments remain lacking despite advances based on patients’
stratifcation. ...
Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex
(Experimental and molecular medicine, 2019)
CDK16 (also known as PCTAIRE1 or PCTK1) is an atypical member of the cyclin-dependent kinase (CDK) family that forms an active complex with cyclin Y (CCNY). Although both proteins have been recently ...
The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration
(Scientific Reports, 2018-08-07)
Colorectal cancer (CRC) is one of the most common cancers worldwide, with 8–10% of these tumours presenting a BRAF (V600E) mutation. Cyclins are known oncogenes deregulated in many cancers, but the role ...
Comprehensive and quantitative analysis of G1 cyclins. A tool for studying the cell cycle
(Public Library of Science, 2019-06-25)
In eukaryotes, the cell cycle is driven by the actions of several cyclin dependent kinases (CDKs) and an array of regulatory proteins called cyclins, due to the cyclical expression patterns of the latter. ...
Defective in mitotic arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation
(American Society for Biochemistry and Molecular Biology, 2013-02)
Progression through the G1 phase of the cell cycle is controlled by diverse cyclin-dependent kinases (CDKs) that might be associated to numerous cyclin isoforms. Given such complexity, regulation of ...
The quantitative changes in the yeast Hsp70 and Hsp90 interactomes upon DNA damage
(Elsevier, 2015-03)
The molecular chaperones Hsp70 and Hsp90 participate in many important cellular processes, including how cells respond to DNA damage. Here we show the results of applied quantitative affinity-purification ...