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Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice
(Elsevier, 2023-05)
Obesity and its associated metabolic comorbidities are a rising global health and social issue, with novel therapeutic approaches urgently needed. Adipose tissue plays a key role in the regulation of ...
Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD
(John Wiley & Sons, Inc., 2020)
The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased drastically due to the global obesity pandemic but at present there are no approved therapies. Here, we aimed to revert high‐fat ...
CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
(Springer Nature, 2023)
Background: Fatty acid metabolism in the hypothalamus has an important role in food intake, but its specific role in AgRP neurons is poorly understood. Here, we examined whether carnitinea palmitoyltransferase ...