Browsing Ciències de la Salut by Subject "Neurociències"
Now showing items 1-6 of 6
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Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids
(Scientific Reports, 2017-09-07)The grey and white matter regions of the mammalian brain consist of both neurons and neuroglial cells. Among the neuroglia, the two macroglia oligodendrocytes and astrocytes are the most abundant cell ... -
Mechanisms of CPT1C-Dependent AMPAR trafficking enhancement
(Frontiers in Molecular Neuroscience, 2018-08-08)In neurons, AMPA receptor (AMPAR) function depends essentially on their constituent components: the ion channel forming subunits and ion channel associated proteins. On the other hand, AMPAR trafficking ... -
Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking
(Journal of Cell Biology, 2020-09)Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ... -
Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking
(Journal of Cell Biology, 2020)Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ... -
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
(eLife, 2019)Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty ... -
X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk
(Scientific Reports, 2013-08-09)X-linked Inhibitor of apoptosis protein (XIAP) has been classically identified as a cell death regulator. Here, we demonstrate a novel function of XIAP as a regulator of neurite outgrowth in neuronal ...