Browsing Ciències de la Salut by Subject "616.4"
Now showing items 1-9 of 9
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Central regulation of brown fat thermogenesis in response to saturated or unsaturated long-chain fatty acids
(International Journal of Molecular Sciences, 2023)Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown ... -
Current challenges for targeting brown fat thermogenesis to combat obesity
(Frontiers in Endocrinology, 2020-10-27)Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of ... -
Hypothalamic endocannabinoids in obesity: an old story with new challenges
(Cellular and Molecular Life Sciences, 2021)The crucial role of the hypothalamus in the pathogenesis of obesity is widely recognized, while the precise molecular and cellular mechanisms involved are the focus of intense research. A disrupted ... -
Hypothalamic regulation of obesity
(International Journal of Molecular Sciences, 2021)Obesity has now reached pandemic proportions and represents a major socioeconomic and health problem in our societies. Up to now, obesity has been considered a medical issue only in high-income countries, ... -
Integrated metabolomics, lipidomics, and genomics reveal the presence of a new biomarker, butanediol glucuronide, associated with the activation of Liver ketogenesis and lipid oxidation by tomato-based sofrito in obese rats
(Antioxidants, 2022)The increasing prevalence of obesity worldwide has promoted research on human metabolism and foods such as sofrito, a tomato and olive oil-based sauce from the Mediterranean diet, has shown beneficial ... -
Limited joint mobility progression in type 1 diabetes: a 15-year follow-up study
(International Journal of Endocrinology, 2018)Objective. To assess the evolution of joint mobility over a period of 15 years in type 1 diabetic patients and healthy controls and to determine whether microalbuminuria is associated with a different ... -
Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD
(Federation of American Societies for Experimental Biology, 2020)The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased drastically due to the global obesity pandemic but at present there are no approved therapies. Here, we aimed to revert high‐fat ... -
Real-world epidemiology of potassium derangements among chronic cardiovascular, metabolic and renal conditions: a population-based analysis
(Clinical Epidemiology, 2020)Background: The aims of the present analysis are to estimate the prevalence of five key chronic cardiovascular, metabolic and renal conditions at the population level, the prevalence of renin–angioten ... -
Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance
(Journal of Neuroendocrinology, 2023)Tackling the growing incidence and prevalence of obesity urgently requires uncovering new molecular pathways with therapeutic potential. The brain, and in particular the hypothalamus, is a major integrator ...