Browsing Ciències de la Salut by Subject "616"

Now showing items 1-20 of 22

    • 90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome 

      Beato, Miguel; Wright, Roni H.G.; Le Dily, François (Journal of Molecular Endocrinology, 2020)
      Gene regulation by steroid hormones has been at the forefront in elucidating the intricacies of transcriptional regulation in eukaryotes ever since the discovery by Karlson and Clever that the insect ...

    • A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials 

      Dashnyam, Khandmaa; El-Fiqi, Ahmed; Olmas Buitrago, Jennifer; Pérez Antoñanzas, Roman; C Knowles, Jonathan; Hae-Won, Kim (2017-04-06)
      Angiogenesis is considered an important issue in the development of biomaterials for the successful regeneration of tissues including bone. While growth factors are commonly used with biomaterials to ...

    • A perspective on the role of physiological stresses in cancer, diabetes and cognitive disease as environmental diseases 

      Esterhuizen, Maranda; Park, Chang-Beom; Kim, Young Jun; Kim, Tae-Young; Yoon, Hakwon; Andres, Frederic; Rodriguez Rodriguez, Rosalia; Tanabe, Shihori (Frontiers in Molecular Biosciences, 2023)
      With rapid industrialization, urbanization, and climate change, the impact of environmental factors on human health is becoming increasingly evident and understanding the complex mechanisms involved is ...

    • A truncated form of IKKa is responsible for specific nuclear IKK activity in colorectal cancer 

      Margalef, Pol; Fernández-Majada, Vanessa; Villanueva, Alberto; Garcia-Carbonell, Ricard; Iglesias, Mar; López, Laura; Martínez-Iniesta, María; Villà-Freixa, Jordi; Mulero, Mari Carmen; Andreu, Montserrat; Torres, Ferran; Mayo, Marty W.; Bigas, Anna; Espinosa, Lluis (Cell Reports, 2012-10-25)
      Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked to cancer progression and metastasis. However, the mechanistic connection between tumorigenesis and ...

    • Atypical cyclin P regulates cancer cell stemness through activation of the WNT pathway 

      Sánchez‑Botet, Abril; Quandt Herrera, Eva; Masip, Núria; Escribá, Rubén; Novellasdemunt, Laura; Gasa Colom, Laura; Li, Vivian S. W.; Raya, Ángel; Clotet Erra, Josep; Ribeiro, Mariana P. C. (Cellular Oncology, 2021)
      Purpose: Cancer stem cells represent a cancer cell subpopulation that has been found to be associated with metastasis and chemoresistance. Therefore, it is vital to identify mechanisms regulating cancer ...

    • Breast cancer-related lymphoedema: risk factors and prediction model 

      Martínez-Jaimez, Patricia; Armora Verdú, Miriam; Garcia Forero, Carlos; Álvarez Salazar, Samantha; Fuster-Linares, Pilar; Monforte-Royo, Cristina; Masia, Jaume (Journal of Advanced Nursing, 2021)
      Aims: To identify the risk factors for lymphoedema following axillary lymph node dissection (ALND) in a European sample and to propose a lymphoedema prediction model for this population. Design: Predictive ...

    • Complete loss of EPCAM immunoexpression identifies EPCAM deletion carriers in MSH2-negative colorectal neoplasia 

      Cuatrecasas, Míriam; Gorostiaga, Iñigo; Riera, Cristina; Saperas, Esteban; Llort, Gemma; Costa, Irmgard; Matias-Guiu, Xavier; Carrato, Cristina; Navarro, Matilde; Pineda, Marta; Dueñas, Núria; Brunet, Joan; Marco, Vicente; Trias, Isabel; Busteros, José Ignacio; Mateu, Gemma; Balaguer, Francesc; Fernández-Figueras, María-Teresa; Esteller, Manel; Musulén, Eva (MDPI, 2020)
      The use of epithelial cell adhesion molecule (EPCAM) immunohistochemistry (IHC) is not included in the colorectal cancer (CRC) screening algorithm to detect Lynch syndrome (LS) patients. The aim of the ...

    • Control in patients with advanced cancer: an interpretative phenomenological study 

      Rodríguez Prat, Andrea; Pergolizzi, Denise; Crespo, Iris; Balaguer, Albert; Porta-Sales, Josep; Monforte-Royo, Cristina (BMC Palliative Care, 2022)
      Background: In the context of life-threatening illness, loss of control is argued as a source of suffering and loss of perceived dignity, whereas having control over the dying process has been seen as ...

    • Correlation between superficial and deep lymphatic systems using magnetic resonance lymphangiography in breast cancer-related lymphedema: clinical implications 

      Abdelfattah, Usama; Martínez-Jaimez, Patricia; Clavero, Juan A.; Bellantonio, Vittoria; Pons, Gemma; Masia, Jaume (Journal of Plastic, Reconstructive & Aesthetic Surgery, 2020)
      Background: Magnetic resonance lymphangiography (MRL) has increased our knowledge of lymphatic anatomy and lymphedema pathophysiology and improved the efficacy of microsurgical procedures to manage ...

    • Correlation between tobacco control policies and mortality of haematological cancers across Europe: an ecological study 

      Mehta, Dipal; Dennis, Rory; Nallamilli, Susanna; Vithayathil, Mathew; Martínez Sánchez, Jose María (Tobacco, Prevention & Cessation, 2021)
      Introduction: To determine the correlation between tobacco control policies and mortality of haematological malignancies: leukemia, lymphoma and multiple myeloma (MM). Methods: Ecological study with the ...

    • Cpt1c downregulation causes plasma membrane remodelling and anthracycline resistance in breast cancer 

      Muley, Helena; Valencia, Karmele; Casas, Josefina; Moreno, Bea; Botella, Luis; Lecanda, Fernando; Fadó, Rut; Casals, Núria (International Journal of Molecular Sciences, 2023)
      Breast cancer (BC) is the most common malignancy in women worldwide. While the main systemic treatment option is anthracycline-containing chemotherapy, chemoresistance continues to be an obstacle to ...

    • Expression of oncogenic drivers in 3D cell culture depends on nuclear ATP synthesis by NUDT5 

      Pickup, Katherine E.; Pardow, Felicitas; Carbonell-Caballero, José; Lioutas, Antonios; Villanueva-Cañas, José Luis; Wright, Roni H.G.; Beato, Miguel (Cancers, 2019)
      The growth of cancer cells as oncospheres in three-dimensional (3D) culture provides a robust cell model for understanding cancer progression, as well as for early drug discovery and validation. We have ...

    • Functional genomics approaches to elucidate vulnerabilities of intrinsic and acquired chemotherapy resistance 

      Cetin, Ronay; Quandt Herrera, Eva; Kaulich, Manuel (Cells, 2021)
      Drug resistance is a commonly unavoidable consequence of cancer treatment that results in therapy failure and disease relapse. Intrinsic (pre-existing) or acquired resistance mechanisms can be drug-specific ...

    • Hidden costs in breast cancer-related lymphedema 

      Martínez-Jaimez, Patricia; Masia, Jaume; Carlos, G. Forero; Fuster, Pilar; Monforte-Royo, Cristina (Elsevier, 2021)
      Breast cancer is the most common neoplastic process in women, with an incidence of 2,088,849 cases in 2018, and an overall 5-year survival of 90% and a 10-year survival of 83%.1 Lymphedema secondary to ...

    • Hormone-control regions mediate steroid receptor–dependent genome organization 

      Le Dily, François; Vidal, Enrique; Cuartero, Yasmina; Quilez Oliete, Javier; Nacht, A. Silvina; Vicent, Guillermo P.; Carbonell-Caballero, José; Sharma, Priyanka; Villanueva-Cañas, José Luis; Ferrari, Roberto; De Llobet, Lara Isabel; Verde, Gaetano; Wright, Roni H.G.; Beato, Miguel (Genome Research, 2019)
      In breast cancer cells, some topologically associating domains (TADs) behave as hormonal gene regulation units, within which gene transcription is coordinately regulated in response to steroid hormones. ...

    • Multidisciplinary preventive intervention for breast cancer-related lymphedema: an international consensus 

      Martínez-Jaimez, Patricia; Fuster-Linares, Pilar; Piller, Neil; Masia, Jaume; Yamamoto, Takumi; López Montoya, Luis Enrique; Monforte-Royo, Cristina (European Journal of Cancer Care, 2022)
      Objective: To establish a consensus regarding the multidisciplinary prevention of breast cancer-related lymphedema (BCRL), taking into account the expert opinion of professional groups from across the ...

    • Multidisciplinary preventive intervention for breast cancer-related lymphedema: an international consensus 

      Martínez-Jaimez, Patricia; Fuster-Linares, Pilar; Piller, Neil; Masia, Jaume; Yamamoto, Takumi; López Montoya, Luis Enrique; Monforte-Royo, Cristina (Wiley, 2022)
      Objective: To establish a consensus regarding the multidisciplinary prevention of breast cancer-related lymphedema (BCRL), taking into account the expert opinion of professional groups from across the ...

    • Real-world epidemiology of potassium derangements among chronic cardiovascular, metabolic and renal conditions: a population-based analysis 

      Jiménez-Marrero, Santiago; Cainzos-Achirica, Miguel; Monterde, David; Garcia-Eroles, Luis; Enjuanes-Grau, Cristina; Yun, Sergi; Garay, Alberto; Moliner, Pedro; Alcoberro, Lidia; Corbella Virós, Xavier; Comin-Colet, Josep (Clinical Epidemiology, 2020)
      Background: The aims of the present analysis are to estimate the prevalence of five key chronic cardiovascular, metabolic and renal conditions at the population level, the prevalence of renin–angioten ...

    • Role of the NUDT enzymes in breast cancer 

      Wright, Roni H.G.; Beato, Miguel (International Journal of Molecular Sciences, 2021)
      Despite global research efforts, breast cancer remains the leading cause of cancer death in women worldwide. The majority of these deaths are due to metastasis occurring years after the initial treatment ...

    • Signalling network of breast cancer cells in response to progesterone 

      Wright, Roni H.G.; Vastolo, Viviana; Quilez Oliete, Javier; Carbonell-Caballero, José; Beato, Miguel (BioRxiv, 2020)
      Breast cancer cells enter into the cell cycle following progestin exposure by the activation of signalling cascades involving a plethora of enzymes, transcription factors and co-factors that transmit ...