Visualitzant Ciències de la Salut per autor/a "Zagmutt, Sebastián"

Ara mostrant els elements 1-10 de 10

    • Central regulation of brown fat thermogenesis in response to saturated or unsaturated long-chain fatty acids 

      Fosch Masllovet, Anna; Rodríguez García, Maria; Miralpeix , Cristina; Zagmutt, Sebastián; Larrañaga Fernandez, Maite; Reguera, Ana Cristina; Garcia-Chica, Jesus; Herrero, Laura; Serra, Dolors; Casals, Nuria; Rodriguez-Rodriguez, Rosalia (International Journal of Molecular Sciences, 2023)
      Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown ...

    • CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst 

      Zagmutt, Sebastián; Mera, Paula; González García, Ismael; Ibeas, Kevin; Romero, María del Mar; Obri, Arnaud; Martin, Beatriz; Esteve Codina, Anna; Soler Vázquez, M. Carmen; Bastias Pérez, Marianela; Cañes, Laia; Augé, Elisabeth; Pelegri, Carme; Vilaplana, Jordi; Ariza, Xavier; García, Jordi; Martinez González, José; Casals, Núria; López, Miguel; Palmiter, Richard; Sanz, Elisenda; Quintana, Albert; Herrero, Laura; Serra, Dolors (Biology of Sex Differences, 2023)
      Background: Fatty acid metabolism in the hypothalamus has an important role in food intake, but its specific role in AgRP neurons is poorly understood. Here, we examined whether carnitinea palmitoyltransferase ...

    • Ghrelin causes a decline in GABA release by reducing fatty acid oxidation in cortex 

      Mir, Joan Francesc; Zagmutt, Sebastián; Lichtenstein, Mathieu P.; García-Villoria, Judit; Weber, Minéia; Gracia, Ana; Fabriàs, Gemma; Casas, Josefina; López, Miguel; Casals i Farré, Núria; Ribes, Antònia; Suñol, Cristina; Herrero Rodríguez, Laura; Serra, Dolors (Springer Nature, 2018)
      Lipid metabolism, specifically fatty acid oxidation (FAO) mediated by carnitine palmitoyltransferase (CPT) 1A, has been described to be an important actor of ghrelin action in hypothalamus. However, it ...

    • Hypothalamic endocannabinoids in obesity: an old story with new challenges 

      Miralpeix Monclús, Cristina; Reguera, Ana Cristina; Fosch, Anna; Zagmutt, Sebastián; Casals i Farré, Núria; Cota, Daniela; Rodríguez-Rodríguez, Rosalía (Cellular and Molecular Life Sciences, 2021)
      The crucial role of the hypothalamus in the pathogenesis of obesity is widely recognized, while the precise molecular and cellular mechanisms involved are the focus of intense research. A disrupted ...

    • Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice 

      Soler Vázquez, M. Carmen; Romero, María del Mar; Todorcevic, Marijana; Delgado, Katia; Calatayud, Carles; Benitez Amaro, Aleyda; La Chica Lhoëst, Maria Teresa; Mera, Paula; Zagmutt, Sebastián; Bastías Pérez, Marianela; Ibeas, Kevin; Casals, Núria; Escolà Gil, Joan Carles; Llorente Cortés, Vicenta; Consiglio, Antonella; Serra, Dolors; Herrero, Laura (Metabolic Engineering, 2023-05)
      Obesity and its associated metabolic comorbidities are a rising global health and social issue, with novel therapeutic approaches urgently needed. Adipose tissue plays a key role in the regulation of ...

    • Integrated metabolomics, lipidomics, and genomics reveal the presence of a new biomarker, butanediol glucuronide, associated with the activation of Liver ketogenesis and lipid oxidation by tomato-based sofrito in obese rats 

      Rinaldi de Alvarenga, José Fernando; Garcia-Aloy, Mar; Ulaszewska, Maria; Zagmutt, Sebastián; Pérez-Montero, Marta; Vrhovsek, Urska; Lamuela-Raventos, Rosa M; Rodriguez-Rodriguez, Rosalia (Antioxidants, 2022)
      The increasing prevalence of obesity worldwide has promoted research on human metabolism and foods such as sofrito, a tomato and olive oil-based sauce from the Mediterranean diet, has shown beneficial ...

    • Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance 

      Garcia-Chica, Jesús; Paraiso, West Kristian; Zagmutt, Sebastián; Fosch, Anna; Reguera, Ana Cristina; Alzina, Sara; Sánchez-García, Laura; Fukushima, Shigeto; Toh, Kazuko; Casals, Núria; Serra, Dolors; Herrero, Laura; Garcia Gomez, Jordi; Kataoka, Kazunori; Ariza, Xavier; Quader, Sabina; Rodriguez-Rodriguez, Rosalia (Biomaterials Science, 2023)
      Targeting brain lipid metabolism is a promising strategy to regulate the energy balance and fight metabolic diseases such as obesity. The development of stable platforms for selective delivery of drugs, ...

    • New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes 

      Fosch, Anna; Zagmutt, Sebastián; Casals i Farré, Núria; Rodríguez-Rodríguez, Rosalía (International Journal of Molecular Sciences, 2021)
      Despite the substantial role played by the hypothalamus in the regulation of energy balance and glucose homeostasis, the exact mechanisms and neuronal circuits underlying this regulation remain poorly ...

    • Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance 

      Rodríguez-Rodríguez, Rosalía; Fosch, Anna; Garcia-Chica, Jesús; Zagmutt, Sebastián; Casals Farré, Nuria (Journal of Neuroendocrinology, 2023)
      Tackling the growing incidence and prevalence of obesity urgently requires uncovering new molecular pathways with therapeutic potential. The brain, and in particular the hypothalamus, is a major integrator ...

    • To be or not to be a fat burner, that is the question for cpt1c in cancer cells 

      Fadó Andrés, Rut; Zagmutt, Sebastián; Herrero, Laura; Muley, Helena; Rodriguez-Rodriguez, Rosalia; Bi, Huichang; Serra, Dolors; Casals, Nuria (Cell Death & Disease, 2023)
      There is an urgent need to identify reliable genetic biomarkers for accurate diagnosis, prognosis, and treatment of different tumor types. Described as a prognostic marker for many tumors is the neuronal ...