Browsing Ciències de la Salut by Author "Saura, Carlos A."
Now showing items 1-5 of 5
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Bone morphogenetic protein-6 promotes cerebellar granule neurons survival by activation of the MEK/ERK/CREB pathway
Barneda-Zahonero, Bruna; Miñano Molina, Alfredo Jesús; Badiola, Nahuai; Fadó Andrés, Rut; Xifró Collsamata, Xavier; Saura, Carlos A.; Rodríguez Álvarez, José (2009-12-15)Bone morphogenetic proteins (BMPs) have been implicated in the generation and postnatal differentiation of cerebellar granule cells (CGCs). Here, we examined the eventual role of BMPs on the survival ... -
Nurr1 protein Is required for N-methyl-d-aspartic acid (NMDA) receptor-mediated neuronal survival
Barneda-Zahonero, Bruna; Servitja, Joan-Marc; Badiola, Nahuai; Miñano Molina, Alfredo Jesús; Fadó Andrés, Rut; Saura, Carlos A.; Rodríguez-Álvarez, José (Journal of Biological Chemistry, 2012-03-30)NMDA receptor (NMDAR) stimulation promotes neuronal survival during brain development. Cerebellar granule cells (CGCs) need NMDAR stimulation to survive and develop. These neurons differentiate and ... -
Proteasomal-mediated degradation of AKAP150 accompanies AMPAR endocytosis during cLTD
Cheng, Wenwen; Siedlecki-Wullich, Dolores; Català-Solsona, Judit; Fábregas, Cristina; Fadó Andrés, Rut; Casals i Farré, Núria; Solé, Montse; Unzeta, Mercedes; Saura, Carlos A.; Rodríguez-Álvarez, José; Miñano Molina, Alfredo Jesús (eNeuro, 2020-03-23)The number and function of synaptic AMPA receptors (AMPARs) tightly regulates excitatory synaptic transmission. Current evidence suggests that AMPARs are inserted into the postsynaptic membrane during ... -
Soluble oligomers of amyloid-β peptide disrupt Membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction
Miñano Molina, Alfredo Jesús; España, Judit; Martín, Elsa; Barneda-Zahonero, Bruna; Fadó Andrés, Rut; Solé, Montse; Trullás, Ramón; Saura, Carlos A.; Rodríguez-Álvarez, José (Journal of Biological Chemistry, 2011-08-05)β-Amyloid (Aβ), a peptide generated from the amyloid precursor protein, is widely believed to underlie the pathophysiology of Alzheimer disease (AD). Emerging evidences suggest that soluble Aβ oligomers ... -
X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk
Fadó Andrés, Rut; Moubarak, Rana S.; Miñano Molina, Alfredo Jesús; Barneda-Zahonero, Bruna; Valero, Jorge; Saura, Carlos A.; Moran, Julio; Comella, Joan X.; Rodríguez-Álvarez, José (Scientific Reports, 2013-08-09)X-linked Inhibitor of apoptosis protein (XIAP) has been classically identified as a cell death regulator. Here, we demonstrate a novel function of XIAP as a regulator of neurite outgrowth in neuronal ...